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There were 89,708 prisoners in Indonesia in April 2006. The majority were charged for narcotics related crimes. Prisons are working at over‐capacity and with miniscule healthcare budgets. There has been an increase of deaths due to AIDS, particularly among people who inject drugs. Official data shows that HIV prevalence averages 22% in prisons. In late 2002, the Ministry of Justice (MOJ) decided to promote HIV/AIDS prevention and care activities for prisoners to prevent the spread of HIV within prisons, and from there to the community as a whole. In 2005, MOJ launched the Indonesian National Strategy for HIV/AIDS Prevention, Care and Support for Prisoners. The Indonesian HIV/AIDS Prevention and Care Project has been actively involved in the design of these programs and supported their implementation in several prisons, together with other organizations. The Indonesian National Strategy is the first of its kind in Asia, and one of only a few dedicated national strategies for HIV/AIDS prevention and care for prisoners. It has enabled education, as well as the provision of condoms, bleach, methadone and antiretroviral therapy for prisoners. This paper describes the National Strategy for HIV/AIDS Prevention, Care and Support for Prisoners, which will help control the HIVepidemic among people who inject drugs and ultimately be beneficial for the community as a whole.