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Your search keyword '"Asymptomatic carriage"' showing total 2 results
Start Over Descriptor "Asymptomatic carriage" Publisher escholarship, university of california
2 results on '"Asymptomatic carriage"'

1. High Asymptomatic Carriage With the Omicron Variant in South Africa

Author

Garrett, Nigel, Tapley, Asa, Andriesen, Jessica, Seocharan, Ishen, Fisher, Leigh H, Bunts, Lisa, Espy, Nicole, Wallis, Carole L, Randhawa, April Kaur, Miner, Maurine D, Ketter, Nzeera, Yacovone, Margaret, Goga, Ameena, Huang, Yunda, Hural, John, Kotze, Philip, Bekker, Linda Gail, Gray, Glenda E, Corey, Lawrence, Ahmed, Khatija, Badal-Faesen, Sharlaa, Barnabas, Shaun, Brumskine, William, Comline, Kim, Diacon, Andreas, Dubula, Thozama, Gill, Katherine, Grobbelaar, Coert, Innes, Craig, Kassim, Sheetal, Kotze, Sheena, Lazarus, Erica, Lombaard, Johannes, Luabeya, Angelique, Maboa, Rebone Molobane, Mahoney, Scott, Mahkaza, Disebo, Malahleha, Moelo, Malan, Daniel, Mngadi, Kathryn, Naicker, Nivashnee, Naicker, Vimla, Naidoo, Logashvari, Nchabeleng, Maphoshane, Rassool, Mohammed, Spooner, Elizabeth, Tempelman, Hugo, Mgodi, Nyaradzo, Dadabhai, Sufia, Makhema, Joe, Nuwagaba-Biribonwoha, Harriet, Samandari, Taraz, Elyanu, Peter James, Chilengi, Roma, Chirenje, Zvavahera, McElrath, Julie, Cohen, Myron, Kublin, James, Gilbert, Peter, Peda, Melissa, Andersen-Nissen, Erica, Ferrari, Guido, Villaran, Manuel, Takalani, Azwidhwi, Gildea, Marianne, Nebergall, Michelle, Sopher, Carrie, Proulx-Burns, Lori, Govender, Dhevium, Sanders, Lisa, Hanke, Jen, Baepanye, Kagisho, Le Roux, Bert, Wilvich, Haven, Sripathy, Smitha, Margineantu, Daciana, Brown, Valerie, Linton, Kim, Howell, Haley, Noronha, Bianca, Nikles, Sarah, Toledano, Alicia, May, Jeanine, El-Khorazaty, Jill, Naidoo, Keshani, Khuto, Kentse, Mayat, Fatima, Fairall, Lara, and Sanne, Ian

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Pneumonia & Influenza, Infectious Diseases, Vaccine Related, Lung, Prevention, Emerging Infectious Diseases, Clinical Research, Pneumonia, Biodefense, Clinical Trials and Supportive Activities, Infection, Good Health and Well Being, COVID-19, Humans, Polymerase Chain Reaction, SARS-CoV-2, South Africa, Omicron variant, asymptomatic carriage, PWH, Ubuntu Study Team, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4 + T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.

Published
2022

2. Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar

Author

Landier, Jordi, Kajeechiwa, Ladda, Thwin, May Myo, Parker, Daniel M, Chaumeau, Victor, Wiladphaingern, Jacher, Imwong, Mallika, Miotto, Olivo, Patumrat, Krittaya, Duanguppama, Jureeporn, Cerqueira, Dominique, Malleret, Benoit, Rénia, Laurent, Nosten, Suphak, von Seidlein, Lorenz, Ling, Clare, Proux, Stéphane, Corbel, Vincent, Simpson, Julie A, Dondorp, Arjen M, White, Nicholas J, and Nosten, François H

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, HIV/AIDS, Clinical Research, Prevention, Malaria, Infectious Diseases, Clinical Trials and Supportive Activities, Vector-Borne Diseases, 3.2 Interventions to alter physical and biological environmental risks, Prevention of disease and conditions, and promotion of well-being, Infection, Good Health and Well Being, Asymptomatic carriage, Mass Drug Administration, Plasmodium falciparum, Plasmodium vivax, artemisinin-resistance, submicroscopic infection, transmission, Biomedical and clinical sciences, Health sciences
Abstract

Background: Artemisinin and partner drug-resistant falciparum malaria is expanding over the Greater Mekong Sub-region (GMS). Eliminating falciparum malaria in the GMS while drugs still retain enough efficacy could prevent global spread of antimalarial resistance. Eliminating malaria rapidly requires targeting the reservoir of asymptomatic parasite carriers. This pilot trial aimed to evaluate the acceptability, safety, feasibility and effectiveness of mass-drug administration (MDA) in reducing malaria in four villages in Eastern Myanmar. Methods: Villages with ≥30% malaria prevalence were selected. Long-lasting insecticidal bednets (LLINs) and access to malaria early diagnosis and treatment (EDT) were provided. Two villages received MDA immediately and two were followed for nine months pre-MDA. MDA consisted of a 3-day supervised course of  dihydroartemisinin-piperaquine and single low-dose primaquine administered monthly for three months. Adverse events (AE) were monitored by interviews and consultations. Malaria prevalence was assessed by ultrasensitive PCR quarterly for 24 months. Symptomatic malaria incidence,entomological indices, and antimalarial resistance markers were monitored. Results: MDA was well tolerated. There were no serious AE and mild to moderate AE were reported in 5.6%(212/3931) interviews. In the smaller villages, participation to three MDA courses was 61% and 57%, compared to 28% and 29% in the larger villages. Baseline prevalence was higher in intervention than in control villages (18.7% (95%CI=16.1-21.6) versus 6.8%(5.2-8.7), p

Published
2017

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