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Start Over Descriptor "Diastereoisomer" Publisher escholarship, university of california
1 results on '"Diastereoisomer"'

1. High-performance liquid chromatography separation of the (S,S)- and (R,S)-forms of S-adenosyl-l-methionine

Author

Zhang, Jianyu and Klinman, Judith P

Subjects
Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Chromatography, High Pressure Liquid, S-Adenosylmethionine, S-adenosyl-L-methionine, Chiral resolution, Diastereoisomer, High-performance liquid chromatography, Radioactive, Separation, S-adenosyl-l-methionine, Analytical Chemistry, Other Chemical Sciences, Biochemistry & Molecular Biology, Biochemistry and cell biology, Analytical chemistry
Abstract

S-adenosyl-l-methionine (AdoMet), an important biological cofactor, exists in two chiral forms, (S,S)- and (R,S)-, only the former of which is biologically active. Here, we have developed a chromatographic method to obtain pure (S,S)-AdoMet using a single C18 column.

Published
2015

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