1. High-resolution HLA-A, HLA-B, and HLA-DRB1 haplotype frequencies from the French Bone Marrow Donor Registry
- Author
-
Pierre-Antoine Gourraud, Amar Baouz, Derek J. Pappas, Federico Garnier, Evelyne Marry, and Marie-Lorraine Balere
- Subjects
Immunology ,Locus (genetics) ,Human leukocyte antigen ,Biology ,Major histocompatibility complex ,Gene Frequency ,Bone Marrow ,Immunology and Allergy ,Humans ,Registries ,Allele ,HLA-DRB1 ,Genetics ,HLA-A Antigens ,Histocompatibility Testing ,Haplotype ,Hematopoietic Stem Cell Transplantation ,General Medicine ,HLA-B ,Tissue Donors ,HLA-A ,Haplotypes ,HLA-B Antigens ,biology.protein ,France ,HLA-DRB1 Chains - Abstract
© 2015 American Society for Histocompatibility and Immunogenetics. We have estimated human leukocyte antigen (HLA) haplotype frequencies using the maximum likelihood mode, which accommodates typing ambiguities. The results of the frequency distribution of the 7015 haplotypes obtained are presented here. These include a total of 114 HLA-A, 185 HLA-B, and 76 HLA-DRB1 unique alleles at each locus. Across all populations, although the most common individual HLA alleles were HLA-A*02:01 (29.0%), HLA-B*07:02 (11.4%), and HLA-DRB1*07:01 (15.9%), the most frequent haplotype was found to be HLA-A*01:01~B*08:01~DRB1*03:01.
- Published
- 2015
- Full Text
- View/download PDF