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Your search keyword '"Gudiksen, Anders"' showing total 3 results
Start Over Author "Gudiksen, Anders" Publisher escholarship, university of california
3 results on '"Gudiksen, Anders"'

1. Erratum to “Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock” [Mol Metab 3 (2014) 29–41]

Author

Dyar, Kenneth A, Ciciliot, Stefano, Wright, Lauren E, Biensø, Rasmus S, Tagliazucchi, Guidantonio Malagoli, Patel, Vishal R, Forcato, Mattia, Peña-Paz, Marcia I, Gudiksen, Anders, Solagna, Francesca, Albiero, Mattia, Moretti, Irene, Eckel-Mahan, Kristin L, Baldi, Pierre, Sassone-Corsi, Paolo, Rizzuto, Rosario, Bicciato, Silvio, Pilegaard, Henriette, Blaauw, Bert, and Schiaffino, Stefano

Subjects
Biochemistry and Cell Biology, Biological Sciences, Physiology, Biochemistry and cell biology
Abstract

[This corrects the article DOI: 10.1016/j.molmet.2013.10.005.].

Published
2014

2. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

Author

Dyar, Kenneth A, Ciciliot, Stefano, Wright, Lauren E, Biensø, Rasmus S, Tagliazucchi, Guidantonio M, Patel, Vishal R, Forcato, Mattia, Paz, Marcia IP, Gudiksen, Anders, Solagna, Francesca, Albiero, Mattia, Moretti, Irene, Eckel-Mahan, Kristin L, Baldi, Pierre, Sassone-Corsi, Paolo, Rizzuto, Rosario, Bicciato, Silvio, Pilegaard, Henriette, Blaauw, Bert, and Schiaffino, Stefano

Subjects
Biochemistry and Cell Biology, Biological Sciences, Sleep Research, Nutrition, Diabetes, Genetics, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Metabolic and endocrine, Bmal1, Circadian rhythms, Glucose metabolism, Glucose uptake, Skeletal muscle, Muscle insulin resistance, 2-DG, 2-Deoxyglucose, BSA, bovine serum albumin, GSEA, Gene Set Enrichment Analysis, HK2, hexokinase 2, KHB, Krebs–Henseleit buffer, PDH, pyruvate dehydrogenase, PDK, PDH kinase, PDP, PDH phosphatase, SCN, suprachiasmatic nucleus, ZT, Zeitgeber time, imKO, inducible muscle-specific Bmal1 knockout, mKO, muscle-specific Bmal1 knockout, Physiology, Biochemistry and cell biology
Abstract

Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal muscle clock has never been explored. We generated conditional and inducible mouse lines with muscle-specific ablation of the core clock gene Bmal1. Skeletal muscles from these mice showed impaired insulin-stimulated glucose uptake with reduced protein levels of GLUT4, the insulin-dependent glucose transporter, and TBC1D1, a Rab-GTPase involved in GLUT4 translocation. Pyruvate dehydrogenase (PDH) activity was also reduced due to altered expression of circadian genes Pdk4 and Pdp1, coding for PDH kinase and phosphatase, respectively. PDH inhibition leads to reduced glucose oxidation and diversion of glycolytic intermediates to alternative metabolic pathways, as revealed by metabolome analysis. The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle.

Published
2014

3. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.

Author

Dyar, Kenneth, Dyar, Kenneth, Ciciliot, Stefano, Wright, Lauren, Biensø, Rasmus, Tagliazucchi, Guidantonio, Patel, Vishal, Forcato, Mattia, Paz, Marcia, Gudiksen, Anders, Solagna, Francesca, Albiero, Mattia, Moretti, Irene, Eckel-Mahan, Kristin, Rizzuto, Rosario, Bicciato, Silvio, Pilegaard, Henriette, Blaauw, Bert, Schiaffino, Stefano, Sassone-Corsi, Paolo, Baldi, Pierre, Dyar, Kenneth, Dyar, Kenneth, Ciciliot, Stefano, Wright, Lauren, Biensø, Rasmus, Tagliazucchi, Guidantonio, Patel, Vishal, Forcato, Mattia, Paz, Marcia, Gudiksen, Anders, Solagna, Francesca, Albiero, Mattia, Moretti, Irene, Eckel-Mahan, Kristin, Rizzuto, Rosario, Bicciato, Silvio, Pilegaard, Henriette, Blaauw, Bert, Schiaffino, Stefano, Sassone-Corsi, Paolo, and Baldi, Pierre

Abstract

Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal muscle clock has never been explored. We generated conditional and inducible mouse lines with muscle-specific ablation of the core clock gene Bmal1. Skeletal muscles from these mice showed impaired insulin-stimulated glucose uptake with reduced protein levels of GLUT4, the insulin-dependent glucose transporter, and TBC1D1, a Rab-GTPase involved in GLUT4 translocation. Pyruvate dehydrogenase (PDH) activity was also reduced due to altered expression of circadian genes Pdk4 and Pdp1, coding for PDH kinase and phosphatase, respectively. PDH inhibition leads to reduced glucose oxidation and diversion of glycolytic intermediates to alternative metabolic pathways, as revealed by metabolome analysis. The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle.

Published
2014

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