1. Control of Amphiphile Self-Assembly via Bioinspired Metal Ion Coordination
- Author
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Craig J. Hawker, Josefin Larsson, Abigail S. Knight, Jianfang Liu, Gang Ren, Remy Vrahas, Raghida Bou Zerdan, Jing M. Ren, and Shay Seguin
- Subjects
chemistry.chemical_classification ,chemistry.chemical_element ,02 engineering and technology ,Zinc ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biochemistry ,Micelle ,Catalysis ,0104 chemical sciences ,Divalent ,Metal ,Colloid and Surface Chemistry ,chemistry ,visual_art ,Polymer chemistry ,Amphiphile ,Chemical Sciences ,visual_art.visual_art_medium ,Chelation ,Self-assembly ,0210 nano-technology ,Cobalt - Abstract
© 2018 American Chemical Society. Inspired by marine siderophores that exhibit a morphological shift upon metal coordination, hybrid peptide-polymer conjugates that assemble into different morphologies based on the nature of the metal ion coordination have been designed. Coupling of a peptide chelator, hexahistidine, with hydrophobic oligostyrene allows a modular strategy to be established for the efficient synthesis and purification of these tunable amphiphiles (oSt(His)6). Remarkably, in the presence of different divalent transition metal ions (Mn, Co, Ni, Cu, Zn, and Cd) a variety of morphologies were observed. Zinc(II), cobalt(II), and copper(II) led to aggregated micelles. Nickel(II) and cadmium(II) produced micelles, and multilamellar vesicles were obtained in the presence of manganese(II). This work highlights the significant potential for transition metal ion coordination as a tool for directing the assembly of synthetic nanomaterials.
- Published
- 2018