Search

Your search keyword '"Kate Naluwu"' showing total 2 results
Start Over Author "Kate Naluwu" Publisher escholarship, university of california
2 results on '"Kate Naluwu"'

1. Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero

Author

Pamela M. Odorizzi, Rachel Budker, Grant Dorsey, Kate Naluwu, Esther Sikyoma, Mayimuna Nalubega, Samuel Wamala, Kenneth Musinguzi, Prasanna Jagannathan, Moses R. Kamya, Diane V. Havlir, Mary Prahl, Abel Kakuru, Tara I. McIntyre, Ann Auma, and Margaret E. Feeney

Subjects
0301 basic medicine, Regulatory T cell, T regulatory cells, malaria, chemical and pharmacologic phenomena, 03 medical and health sciences, Rare Diseases, Immune system, Clinical Research, medicine, 2.2 Factors relating to the physical environment, sex, IL-2 receptor, Aetiology, Interleukin-7 receptor, Pediatric, vaccines, business.industry, Brief Report, FOXP3, medicine.disease, immunity, 3. Good health, Vector-Borne Diseases, Good Health and Well Being, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Oncology, In utero, Cord blood, Immunology, Infection, business, Malaria
Abstract

Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed birth cohort of mother-infant pairs in Uganda by sex. We found that frequencies of cord blood regulatory T cell ([Treg] CD4+CD25+FoxP3+CD127lo/−) differed by infant sex, with significantly lower frequencies of Tregs in female than in male neonates (P = .006). When stratified by in utero malaria exposure status, this difference was observed in the exposed, but not in the unexposed infants.

Published
2017

2. Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation

Author

Diane V. Havlir, Lila A. Farrington, Margaret E. Feeney, Samuel Wamala, Prasanna Jagannathan, John Ategeka, Abel Kakuru, Mary Prahl, Patience Nayebare, Esther Sikyoma, Moses R. Kamya, Kate Naluwu, Tara I. McIntyre, Pamela M. Odorizzi, Kenneth Musinguzi, Hilary M. Vance, Rachel Budker, Ann Auma, Mayimuna Nalubega, and Grant Dorsey

Subjects
0301 basic medicine, CD4-Positive T-Lymphocytes, Plasmodium, Placenta Diseases, Reproductive health and childbirth, Dendritic cells, Immune tolerance, Cohort Studies, 0302 clinical medicine, Pregnancy, Pregnancy-associated malaria, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, 030212 general & internal medicine, IL-2 receptor, Aetiology, Pregnancy Complications, Infectious, Pediatric, Infectious, FOXP3, Fetal Blood, Flow Cytometry, 3. Good health, Infectious Diseases, In utero, Medical Microbiology, Cord blood, Public Health and Health Services, HIV/AIDS, Female, Infection, Pediatric Research Initiative, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, CD4 T cells, Biology, Fetal immune response, Microbiology, lcsh:Infectious and parasitic diseases, Immunophenotyping, 03 medical and health sciences, Young Adult, Rare Diseases, Immune system, Clinical Research, Tropical Medicine, parasitic diseases, medicine, Humans, lcsh:RC109-216, Conditions Affecting the Embryonic and Fetal Periods, Prevention, Inflammatory and immune system, Research, Infant, Newborn, Infant, Loop-mediated isothermal amplification, Dendritic Cells, Perinatal Period - Conditions Originating in Perinatal Period, medicine.disease, Newborn, Malaria, Vector-Borne Diseases, Pregnancy Complications, Good Health and Well Being, 030104 developmental biology, Immunology, Parasitology
Abstract

BackgroundIn malaria-endemic areas, the first exposure to malaria antigens often occurs in utero when the fetal immune system is poised towards the development of tolerance. Children exposed to placental malaria have an increased risk of clinical malaria in the first few years of life compared to unexposed children. Recent work has suggested the potential of pregnancy-associated malaria to induce immune tolerance in children living in malaria-endemic areas. A study was completed to evaluate the effect of malaria exposure during pregnancy on fetal immune tolerance and effector responses.MethodsUsing cord blood samples from a cohort of mother-infant pairs followed from early in pregnancy until delivery, flow cytometry analysis was completed to assess the relationship between pregnancy-associated malaria and fetal cord blood CD4 and dendritic cell phenotypes.ResultsCord blood FoxP3+ Treg counts were higher in infants born to mothers with Plasmodium parasitaemia early in pregnancy (12-20weeks of gestation; p=0.048), but there was no association between Treg counts and the presence of parasites in the placenta at the time of delivery (by loop-mediated isothermal amplification (LAMP); p=0.810). In contrast, higher frequencies of activated CD4 T cells (CD25+FoxP3-CD127+) were observed in the cord blood of neonates with active placental Plasmodium infection at the time of delivery (p=0.035). This population exhibited evidence of effector memory differentiation, suggesting priming of effector T cells in utero. Lastly, myeloid dendritic cells were higher in the cord blood of infants with histopathologic evidence of placental malaria (p&nbsp

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results