1. Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis
- Author
-
Chadeau-Hyam, M, Vermeulen, RCH, Hebels, DGAJ, Castagné, R, Campanella, G, Portengen, L, Kelly, RS, Bergdahl, IA, Melin, B, Hallmans, G, Palli, D, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, de Kok, TMCM, Smith, MT, Kleinjans, JCS, Vineis, P, Kyrtopoulos, SA, consortium, on behalf of the EnviroGenoMarkers project, Georgiadis, P, Botsivali, M, Papadopoulou, C, Chatziioannou, A, Valavanis, I, Gottschalk, R, van Leeuwen, D, Timmermans, L, Keun, HC, Athersuch, TJ, Lenner, P, Bendinelli, B, Stephanou, EG, Myridakis, A, Kogevinas, M, Saberi-Hosnijeh, F, Fazzo, L, de Santis, M, Comba, P, Kiviranta, H, Rantakokko, P, Airaksinen, R, Ruokojarvi, P, Gilthorpe, MS, Fleming, S, Fleming, T, Tu, Y-K, Jonsson, B, Lundh, T, Chien, K-L, Chen, WJ, Lee, W-C, Hsiao, CK, Kuo, P-H, Hung, H, and Liao, S-F
- Subjects
Genetic Testing ,Lymphoma ,Orphan Drug ,Genetics ,Hematology ,Cancer ,Rare Diseases ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Adult ,Aged ,Biomarkers ,Tumor ,Case-Control Studies ,Female ,Genome ,Human ,Humans ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Models ,Genetic ,Principal Component Analysis ,Prospective Studies ,Transcriptome ,epidemiology ,lymphoma ,chronic lymphocytic leukemia ,mRNA analyses ,prospective cohort ,EnviroGenoMarkers project consortium ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundB-cell lymphomas are a diverse group of hematological neoplasms with differential etiology and clinical trajectories. Increased insights in the etiology and the discovery of prediagnostic markers have the potential to improve the clinical course of these neoplasms.MethodsWe investigated in a prospective study global gene expression in peripheral blood mononuclear cells of 263 incident B-cell lymphoma cases, diagnosed between 1 and 17 years after blood sample collection, and 439 controls, nested within two European cohorts.ResultsOur analyses identified only transcriptomic markers for specific lymphoma subtypes; few markers of multiple myeloma (N = 3), and 745 differentially expressed genes in relation to future risk of chronic lymphocytic leukemia (CLL). The strongest of these associations were consistently found in both cohorts and were related to (B-) cell signaling networks and immune system regulation pathways. CLL markers exhibited very high predictive abilities of disease onset even in cases diagnosed more than 10 years after blood collection.ConclusionsThis is the first investigation on blood cell global gene expression and future risk of B-cell lymphomas. We mainly identified genes in relation to future risk of CLL that are involved in biological pathways, which appear to be mechanistically involved in CLL pathogenesis. Many but not all of the top hits we identified have been reported previously in studies based on tumor tissues, therefore suggesting that a mixture of preclinical and early disease markers can be detected several years before CLL clinical diagnosis.
- Published
- 2014