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Your search keyword '"Laboratory rat"' showing total 3 results
Start Over Descriptor "Laboratory rat" Publisher escholarship, university of california
3 results on '"Laboratory rat"'

1. Bridging the species gap in translational research for neurodevelopmental disorders

Author

Ryan, AM, Berman, RF, and Bauman, MD

Subjects
Biological Psychology, Cognitive and Computational Psychology, Psychology, Neurosciences, Brain Disorders, Behavioral and Social Science, Intellectual and Developmental Disabilities (IDD), Mental Health, Basic Behavioral and Social Science, Neurological, Animals, Disease Models, Animal, Humans, Macaca mulatta, Neurodevelopmental Disorders, Rats, Translational Research, Biomedical, Animal models, Laboratory rat, Nonhuman primate, Rhesus macaque, Medical and Health Sciences, Psychology and Cognitive Sciences, Behavioral Science & Comparative Psychology, Biological psychology, Cognitive and computational psychology
Abstract

The prevalence and societal impact of neurodevelopmental disorders (NDDs) continue to increase despite years of research in both patient populations and animal models. There remains an urgent need for translational efforts between clinical and preclinical research to (i) identify and evaluate putative causes of NDD, (ii) determine their underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches, and (iv) translate basic research into safe and effective clinical practices. Given the complexity behind potential causes and behaviors affected by NDDs, modeling these uniquely human brain disorders in animals will require that we capitalize on unique advantages of a diverse array of species. While much NDD research has been conducted in more traditional animal models such as the mouse, ultimately, we may benefit from creating animal models with species that have a more sophisticated social behavior repertoire such as the rat (Rattus norvegicus) or species that more closely related to humans, such as the rhesus macaque (Macaca mulatta). Here, we highlight the rat and rhesus macaque models for their role in previous psychological research discoveries, current efforts to understand the neurobiology of NDDs, and focus on the convergence of behavior outcome measures that parallel features of human NDDs.

Published
2019

2. Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders

Author

Ruth K. Weir, Katherine M. Ku, Jill L. Silverman, Robert F. Berman, Melissa D. Bauman, and Pellis, Sergio

Subjects
0301 basic medicine, Male, Research Facilities, Autism Spectrum Disorder, Autism, Social Sciences, Social identity approach, Rats, Sprague-Dawley, Mice, 0302 clinical medicine, Psychology, Young adult, Mammals, Pediatric, Multidisciplinary, Animal Behavior, Animal Models, Sensory Gating, Laboratory rat, medicine.anatomical_structure, Phenotype, Mental Health, Autism spectrum disorder, Vertebrates, Anxiety, Medicine, Female, medicine.symptom, Research Laboratories, Research Article, General Science & Technology, Science, Intellectual and Developmental Disabilities (IDD), Biology, Research and Analysis Methods, Rodents, Basic Behavioral and Social Science, 03 medical and health sciences, Model Organisms, Species Specificity, Behavioral and Social Science, medicine, Animals, Learning, Rats, Long-Evans, Social Behavior, Behavior, Sensory gating, Animal, Organisms, Neurosciences, Biology and Life Sciences, Long-Evans, Social Play, Collective Animal Behavior, medicine.disease, Rats, Brain Disorders, Young Adults, Disease Models, Animal, 030104 developmental biology, Age Groups, Amniotes, People and Places, Developmental Psychology, Disease Models, Recreation, Population Groupings, Collective animal behavior, Sprague-Dawley, Stereotyped Behavior, Zoology, Neuroscience, 030217 neurology & neurosurgery
Abstract

The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social behavior. The present study was carried out to compare two commonly used strains of laboratory rats, Sprague-Dawley (SD) and Long-Evans (LE), between the ages of postnatal day (PND) 26-56 using high-throughput behavioral phenotyping tools commonly used in mouse models of ASD that we have adapted for use in rats. We detected few differences between young SD and LE strains on standard assays of exploration, sensorimotor gating, anxiety, repetitive behaviors, and learning. Both SD and LE strains also demonstrated sociability in the 3-chamber social approach test as indexed by spending more time in the social chamber with a constrained age/strain/sex matched novel partner than in an identical chamber without a partner. Pronounced differences between the two strains were, however, detected when the rats were allowed to freely interact with a novel partner in the social dyad paradigm. The SD rats in this particular testing paradigm engaged in play more frequently and for longer durations than the LE rats at both juvenile and young adult developmental time points. Results from this study that are particularly relevant for developing preclinical ASD models in rats are threefold: (i) commonly utilized strains exhibit unique patterns of social interactions, including strain-specific play behaviors, (ii) the testing environment may profoundly influence the expression of strain-specific social behavior and (iii) simple, automated measures of sociability may not capture the complexities of rat social interactions.

Published
2016

3. Environmentally induced changes in the dimensions of the rat cerebrum

Author

Amelia Torok, Robert A. Cummins, Roger Walsh, and O. E. Budtz-Olsen

Subjects
Male, medicine.medical_specialty, Biology, Environment, Behavioral Neuroscience, Developmental Neuroscience, Group differences, Species Specificity, Internal medicine, Animals, Laboratory, Developmental and Educational Psychology, medicine, Animals, Cerebrum, Body Weight, Age Factors, Brain, Anatomy, Organ Size, Housing, Animal, Laboratory rat, Rats, medicine.anatomical_structure, Endocrinology, Social Isolation, Environmental complexity, Brain weight, Developmental Biology
Abstract

Two groups of rats were reared under conditions of environmental complexity while their littermates were reared in isolation. Cerebral length and width were measured following 30 and 80 days of differential rearing. In the 30‐day group differences in neither cerebral length nor width reached significant levels but the product of the 2 parameters was 2.1 % (p < .02) greater in the stimulated animals. In the 80‐day group cerebral length was significantly greater (p < .001) in the stimulated animals than in their isolated littermates, but no significant differences in cerebral width were detected.

Published
1971

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