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Start Over Author "Lene Lundvall" Publisher escholarship, university of california
3 results on '"Lene Lundvall"'

1. Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

Author

Kate, Lawrenson, Edwin S, Iversen, Jonathan, Tyrer, Rachel Palmieri, Weber, Patrick, Concannon, Dennis J, Hazelett, Qiyuan, Li, Jeffrey R, Marks, Andrew, Berchuck, Janet M, Lee, Katja K H, Aben, Hoda, Anton-Culver, Natalia, Antonenkova, Elisa V, Bandera, Yukie, Bean, Matthias W, Beckmann, Maria, Bisogna, Line, Bjorge, Natalia, Bogdanova, Louise A, Brinton, Angela, Brooks-Wilson, Fiona, Bruinsma, Ralf, Butzow, Ian G, Campbell, Karen, Carty, Jenny, Chang-Claude, Georgia, Chenevix-Trench, Ann, Chen, Zhihua, Chen, Linda S, Cook, Daniel W, Cramer, Julie M, Cunningham, Cezary, Cybulski, Joanna, Plisiecka-Halasa, Joe, Dennis, Ed, Dicks, Jennifer A, Doherty, Thilo, Dörk, Andreas, du Bois, Diana, Eccles, Douglas T, Easton, Robert P, Edwards, Ursula, Eilber, Arif B, Ekici, Peter A, Fasching, Brooke L, Fridley, Yu-Tang, Gao, Aleksandra, Gentry-Maharaj, Graham G, Giles, Rosalind, Glasspool, Ellen L, Goode, Marc T, Goodman, Jacek, Gronwald, Philipp, Harter, Hanis Nazihah, Hasmad, Alexander, Hein, Florian, Heitz, Michelle A T, Hildebrandt, Peter, Hillemanns, Estrid, Hogdall, Claus, Hogdall, Satoyo, Hosono, Anna, Jakubowska, James, Paul, Allan, Jensen, Beth Y, Karlan, Susanne Kruger, Kjaer, Linda E, Kelemen, Melissa, Kellar, Joseph L, Kelley, Lambertus A, Kiemeney, Camilla, Krakstad, Diether, Lambrechts, Sandrina, Lambrechts, Nhu D, Le, Alice W, Lee, Rikki, Cannioto, Arto, Leminen, Jenny, Lester, Douglas A, Levine, Dong, Liang, Jolanta, Lissowska, Karen, Lu, Jan, Lubinski, Lene, Lundvall, Leon F A G, Massuger, Keitaro, Matsuo, Valerie, McGuire, John R, McLaughlin, Heli, Nevanlinna, Iain, McNeish, Usha, Menon, Francesmary, Modugno, Kirsten B, Moysich, Steven A, Narod, Lotte, Nedergaard, Roberta B, Ness, Mat Adenan, Noor Azmi, Kunle, Odunsi, Sara H, Olson, Irene, Orlow, Sandra, Orsulic, Celeste L, Pearce, Tanja, Pejovic, Liisa M, Pelttari, Jennifer, Permuth-Wey, Catherine M, Phelan, Malcolm C, Pike, Elizabeth M, Poole, Susan J, Ramus, Harvey A, Risch, Barry, Rosen, Mary Anne, Rossing, Joseph H, Rothstein, Anja, Rudolph, Ingo B, Runnebaum, Iwona K, Rzepecka, Helga B, Salvesen, Agnieszka, Budzilowska, Thomas A, Sellers, Xiao-Ou, Shu, Yurii B, Shvetsov, Nadeem, Siddiqui, Weiva, Sieh, Honglin, Song, Melissa C, Southey, Lara, Sucheston, Ingvild L, Tangen, Soo-Hwang, Teo, Kathryn L, Terry, Pamela J, Thompson, Agnieszka, Timorek, Shelley S, Tworoger, Els, Van Nieuwenhuysen, Ignace, Vergote, Robert A, Vierkant, Shan, Wang-Gohrke, Christine, Walsh, Nicolas, Wentzensen, Alice S, Whittemore, Kristine G, Wicklund, Lynne R, Wilkens, Yin-Ling, Woo, Xifeng, Wu, Anna H, Wu, Hannah, Yang, Wei, Zheng, Argyrios, Ziogas, Gerhard A, Coetzee, Matthew L, Freedman, Alvaro N A, Monteiro, Joanna, Moes-Sosnowska, Jolanta, Kupryjanczyk, Paul D, Pharoah, Simon A, Gayther, and Joellen M, Schildkraut

Subjects
Cancer Research, endocrine system diseases, Genome-wide association study, Carcinoma, Ovarian Epithelial, Risk Factors, Neoplasms, Ovarian Epithelial, 2.1 Biological and endogenous factors, Neoplasms, Glandular and Epithelial, Aetiology, skin and connective tissue diseases, Cancer, Genetics, Ovarian Neoplasms, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Glandular and Epithelial, General Medicine, Single Nucleotide, female genital diseases and pregnancy complications, Ovarian Cancer, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Female, Biotechnology, Australian Ovarian Cancer Study Group, Quantitative Trait Loci, Oncology and Carcinogenesis, Locus (genetics), Single-nucleotide polymorphism, Original Manuscript, Biology, Polymorphism, Single Nucleotide, Rare Diseases, Clinical Research, Australian Cancer Study, SNP, Humans, Genetic Predisposition to Disease, Genetic Testing, Oncology & Carcinogenesis, 1000 Genomes Project, Polymorphism, CHEK2, Genetic association, Prevention, Carcinoma, Human Genome, Checkpoint Kinase 2, Genetic Loci, Case-Control Studies, Cancer research, Imputation (genetics), Genome-Wide Association Study
Abstract

Contains fulltext : 152042.pdf (Publisher’s version ) (Closed access) Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide polymorphisms (SNPs) and indels] in DNA repair genes and EOC risk. We genotyped 2896 common variants at 143 gene loci in DNA samples from 15 397 patients with invasive EOC and controls. We found evidence of associations with EOC risk for variants at FANCA, EXO1, E2F4, E2F2, CREB5 and CHEK2 genes (P

Published
2015

2. Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study

Author

Linda E. Kelemen, Argyrios Ziogas, Celeste Leigh Pearce, Karen Lu, Agnieszka Dansonka-Mieszkowska, Melissa C. Southey, Elisa V. Bandera, Hoda Anton-Culver, Nadeem Siddiqui, Kristine G. Wicklund, Hannah P. Yang, Graham G. Giles, Georgia Chenevix-Trench, Anna Jakubowska, Paul D.P. Pharoah, Susanne K. Kjaer, Jonathan Tyrer, Catherine M. Phelan, Honglin Song, Lambertus A. Kiemeney, John R. McLaughlin, Arto Leminen, Jennifer A. Doherty, Irene Orlow, Natalia Bogdanova, Helga B. Salvesen, Lara E. Sucheston-Campbell, Liisa M. Pelttari, Alexander Hein, Jenny Lester, Lynne R. Wilkens, Alice W. Lee, Valerie McGuire, Yukie Bean, Julie M. Cunningham, Diana Eccles, Rosalind Glasspool, Patricia Harrington, Shelley S. Tworoger, Joseph H. Rothstein, Allan Jensen, Rachel Palmieri Weber, Ian G. Campbell, Nhu D. Le, Matthias W. Beckmann, Marc T. Goodman, Sandra Orsulic, Shan Wang-Gohrke, Elizabeth M. Poole, Usha Menon, Harvey A. Risch, Anja Rudolph, Tanja Pejovic, Lotte Nedergaard, Dong Liang, Jan Lubinski, Els Van Nieuwenhuysen, Arif B. Ekici, Camilla Krakstad, Ignace Vergote, Robert A. Vierkant, Ingvild L. Tangen, Ursula Eilber, Florian Heitz, Beth Y. Karlan, Diether Lambrechts, Brooke L. Fridley, Malcolm C. Pike, Anne M. van Altena, Alice S. Whittemore, Estrid Høgdall, Kunle Odunsi, Mary Anne Rossing, Thilo Dörk, Douglas A. Levine, Yurii B. Shvetsov, Joellen M. Schildkraut, Daniel O. Stram, Francesmary Modugno, Melissa Kellar, Christine Walsh, Roberta B. Ness, James Paul, Line Bjørge, Edwin S. Iversen, Robert P. Edwards, Louise A. Brinton, Joanna Plisiecka-Halasa, Anna H. Wu, Linda S. Cook, Joseph L. Kelley, Jolanta Kupryjanczyk, Nicolas Wentzensen, Matthias Dürst, Andreas du Bois, Aleksandra Gentry-Maharaj, Jenny Chang-Claude, Cezary Cybulski, Douglas A. Stram, Michelle A.T. Hildebrandt, Weiva Sieh, Kathryn L. Terry, Ira Schwaab, Sara H. Olson, Iain A. McNeish, Ellen L. Goode, Heli Nevanlinna, Maria Bisogna, Jolanta Lissowska, Katja K.H. Aben, Leon F.A.G. Massuger, Beata Spiewankiewicz, Peter A. Fasching, Fiona Bruinsma, Claus Høgdall, Kirsten B. Moysich, Philipp Harter, Jacek Gronwald, Xifeng Wu, Lene Lundvall, Andrew Berchuck, Peter Hillemanns, Pamela J. Thompson, Karen Carty, Susan J. Ramus, Emily Myers, Angela Brooks-Wilson, Ingo B. Runnebaum, and Daniel W. Cramer

Subjects
Candidate gene, Aging, Genome-wide association study, Bioinformatics, Gene, FSHB, Risk Factors, Genotype, 2.1 Biological and endogenous factors, Aetiology, Cancer, Genetics, Ovarian Neoplasms, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Tumor, Obstetrics and Gynecology, Single Nucleotide, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Oncology, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Female, Signal Transduction, Biotechnology, Australian Ovarian Cancer Study Group, Genetic Markers, endocrine system, Oncology and Carcinogenesis, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Article, Paediatrics and Reproductive Medicine, Rare Diseases, Ovarian cancer, Australian Cancer Study, medicine, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Genetic variation, Oncology & Carcinogenesis, Polymorphism, Prevention, Human Genome, Case-control study, medicine.disease, INHBB, Logistic Models, Case-Control Studies, Polymorphisms, Gonadotropins, Biomarkers, Genome-Wide Association Study
Abstract

Contains fulltext : 155211.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Ovarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiologic role of gonadotropins, an assessment of how variability in genes involved in the gonadotropin signaling pathway impacts disease risk is warranted. METHODS: Genetic data from 41 ovarian cancer study sites were pooled and unconditional logistic regression was used to evaluate whether any of the 2185 SNPs from 11 gonadotropin signaling pathway genes was associated with ovarian cancer risk. A burden test using the admixture likelihood (AML) method was also used to evaluate gene-level associations. RESULTS: We did not find any genome-wide significant associations between individual SNPs and ovarian cancer risk. However, there was some suggestion of gene-level associations for four gonadotropin signaling pathway genes: INHBB (p=0.045, mucinous), LHCGR (p=0.046, high-grade serous), GNRH (p=0.041, high-grade serous), and FSHB (p=0.036, overall invasive). There was also suggestive evidence for INHA (p=0.060, overall invasive). CONCLUSIONS: Ovarian cancer studies have limited sample numbers, thus fewer genome-wide susceptibility alleles, with only modest associations, have been identified relative to breast and prostate cancers. We have evaluated the majority of ovarian cancer studies with biological samples, to our knowledge, leaving no opportunity for replication. Using both our understanding of biology and powerful gene-level tests, we have identified four putative ovarian cancer loci near INHBB, LHCGR, GNRH, and FSHB that warrant a second look if larger sample sizes and denser genotype chips become available.

Published
2015

3. ABCA transporter gene expression and poor outcome in epithelial ovarian cancer

Author

Bo Gao, Nadeem Siddiqui, Julie M. Cunningham, Allan Jensen, Joshy George, Yasushi Yatabe, Thomas A. Sellers, Andreas du Bois, Christine Walsh, Arif B. Ekici, Amanda J. Russell, Rebekka T. Williams, Ignace Vergote, Philipp Harter, Claus Høgdall, Yi Lu, Bob Brown, Ellen L. Goode, Ed Iversen, Satoyo Hosono, James M. Flanagan, S.K. Kjaer, Michelle Haber, Michelle J. Henderson, Stuart MacGregor, Jonathan Beesley, Keitaro Matsuo, Sandra Orsulic, Joellen M. Schildkraut, Anna deFazio, Xiaoqing Chen, Matthias W. Beckmann, Sharon E. Johnatty, Claudia Flemming, Yukie Bean, Diether Lambrechts, Catherine Emmanuel, Sandrina Lambrechts, Ellen L. Hedditch, Alexander Hein, Toru Nakanishi, David D.L. Bowtell, Svend Aage Engelholm, Rachel Palmieri Weber, Murray D. Norris, Brooke L. Fridley, Ira Schwaab, Jenny Lester, Georgia Chenevix-Trench, Andrew Berchuck, Estrid Høgdall, Peter A. Fasching, Tanja Pejovic, Florian Heitz, Beth Y. Karlan, Paul R. Harnett, Evelyn Despierre, Lene Lundvall, and Michelle D Metcalf

Subjects
Cancer Research, endocrine system diseases, Genome-wide association study, Kaplan-Meier Estimate, Carcinoma, Ovarian Epithelial, Real-Time Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Article, Metastasis, Cell Movement, Medizinische Fakultät, medicine, Humans, Neoplasms, Glandular and Epithelial, RNA, Messenger, ddc:610, Ovarian Neoplasms, Regulation of gene expression, biology, medicine.disease, Debulking, Cystadenocarcinoma, Serous, Gene Expression Regulation, Neoplastic, Serous fluid, Real-time polymerase chain reaction, Oncology, ABCA1, Neoplastic Stem Cells, biology.protein, Cancer research, ATP-Binding Cassette Transporters, Female, Neoplasm Grading, Ovarian cancer, ATP Binding Cassette Transporter 1, Genome-Wide Association Study
Abstract

Background ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown. Methods The relationship between clinical outcomes and ABC transporter gene expression in two independent cohorts of high-grade serous EOC tumors was assessed with real-time quantitative polymerase chain reaction, analysis of expression microarray data, and immunohistochemistry. Associations between clinical outcomes and ABCA transporter gene single nucleotide polymorphisms were tested in a genome-wide association study. Impact of short interfering RNA-mediated gene suppression was determined by colony forming and migration assays. Association with survival was assessed with Kaplan-Meier analysis and log-rank tests. All statistical tests were two-sided. Results Associations with outcome were observed with ABC transporters of the A subfamily, but not with multidrug transporters. High-level expression of ABCA1, ABCA6, ABCA8, and ABCA9 in primary tumors was statistically significantly associated with reduced survival in serous ovarian cancer patients. Low levels of ABCA5 and the C-allele of rs536009 were associated with shorter overall survival (hazard ratio for death = 1.50; 95% confidence interval [CI] =1.26 to 1.79; P = 6.5e-6). The combined expression pattern of ABCA1, ABCA5, and either ABCA8 or ABCA9 was associated with particularly poor outcome (mean overall survival in group with adverse ABCA1, ABCA5 and ABCA9 gene expression = 33.2 months, 95% CI = 26.4 to 40.1; vs 55.3 months in the group with favorable ABCA gene expression, 95% CI = 49.8 to 60.8; P =. 001), independently of tumor stage or surgical debulking status. Suppression of cholesterol transporter ABCA1 inhibited ovarian cancer cell growth and migration in vitro, and statin treatment reduced ovarian cancer cell migration. Conclusions Expression of ABCA transporters was associated with poor outcome in serous ovarian cancer, implicating lipid trafficking as a potentially important process in EOC. © 2014 The Author 2014. Published by Oxford University Press. All rights reserved.

Published
2014

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