1. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study
- Author
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Harold I. Feldman, Peter A. Kanetsky, Marty Schreiber, Alan S. Go, Jiang He, Parasuram Krishnamoorthy, Catherine McLaughlin, Michael J. Fischer, Nehal N. Mehta, Crystal A. Gadegbeku, Stephen R. Master, Rachana Shah, Raymond R. Townsend, Melanie Wolman, Gregory J. Matthews, Rhia Shah, Andrea S. Foulkes, Daniel J. Rader, Parth N Patel, Muredach P. Reilly, Dominic S. Raj, Jing Chen, John W. Kusek, and Matthew J. Budoff
- Subjects
Male ,Aging ,Kidney Disease ,Myocardial Infarction ,Kaplan-Meier Estimate ,Chronic Renal Insufficiency Cohort (CRIC) Study Investigators ,Cardiorespiratory Medicine and Haematology ,Cardiovascular ,chemistry.chemical_compound ,Medicine ,Myocardial infarction ,Prospective Studies ,Renal Insufficiency ,Chronic ,Prospective cohort study ,Incidental Findings ,Middle Aged ,CXCL12 ,Prognosis ,Heart Disease ,Cohort ,Cardiology ,Female ,Chemokines ,Cardiology and Cardiovascular Medicine ,Cohort study ,Adult ,medicine.medical_specialty ,Clinical Sciences ,Renal and urogenital ,Renal function ,Young Adult ,Clinical Research ,Diabetes mellitus ,Internal medicine ,Humans ,Renal Insufficiency, Chronic ,Heart Disease - Coronary Heart Disease ,Aged ,Creatinine ,business.industry ,Prevention ,medicine.disease ,Atherosclerosis ,Chemokine CXCL12 ,Endocrinology ,Cross-Sectional Studies ,Good Health and Well Being ,chemistry ,Cardiovascular System & Hematology ,business ,Biomarkers ,Kidney disease - Abstract
AimsGenome-wide association studies revealed an association between a locus at 10q11, downstream from CXCL12, and myocardial infarction (MI). However, the relationship among plasma CXCL12, cardiovascular disease (CVD) risk factors, incident MI, and death is unknown.Methods and resultsWe analysed study-entry plasma CXCL12 levels in 3687 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a prospective study of cardiovascular and kidney outcomes in chronic kidney disease (CKD) patients. Mean follow-up was 6 years for incident MI or death. Plasma CXCL12 levels were positively associated with several cardiovascular risk factors (age, hypertension, diabetes, hypercholesterolaemia), lower estimated glomerular filtration rate (eGFR), and higher inflammatory cytokine levels (P < 0.05). In fully adjusted models, higher study-entry CXCL12 was associated with increased odds of prevalent CVD (OR 1.23; 95% confidence interval 1.14, 1.33, P < 0.001) for one standard deviation (SD) increase in CXCL12. Similarly, one SD higher CXCL12 increased the hazard of incident MI (1.26; 1.09,1.45, P < 0.001), death (1.20; 1.09,1.33, P < 0.001), and combined MI/death (1.23; 1.13-1.34, P < 0.001) adjusting for demographic factors, known CVD risk factors, and inflammatory markers and remained significant for MI (1.19; 1.03,1.39, P = 0.01) and the combined MI/death (1.13; 1.03,1.24, P = 0.01) after further controlling for eGFR and urinary albumin:creatinine ratio.ConclusionsIn CKD, higher plasma CXCL12 was associated with CVD risk factors and prevalent CVD as well as the hazard of incident MI and death. Further studies are required to establish if plasma CXCL12 reflect causal actions at the vessel wall and is a tool for genomic and therapeutic trials.
- Published
- 2014