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Start Over Author "Zerbo O" Publisher escholarship, university of california
3 results on '"Zerbo O"'

1. Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation

Author

Jones, KL, Croen, LA, Yoshida, CK, Heuer, L, Hansen, R, Zerbo, O, DeLorenze, GN, Kharrazi, M, Yolken, R, Ashwood, P, and Van de Water, J

Subjects
Cognitive and Computational Psychology, Biomedical and Clinical Sciences, Psychology, Clinical Research, Mental Health, Autism, Intellectual and Developmental Disabilities (IDD), Brain Disorders, Behavioral and Social Science, Pediatric, 2.1 Biological and endogenous factors, Mental health, Adult, Autism Spectrum Disorder, Autistic Disorder, Case-Control Studies, Chemokines, Child, Child Development, Child Development Disorders, Pervasive, Child, Preschool, Cytokines, Developmental Disabilities, Female, Humans, Infant, Intellectual Disability, Male, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However, few studies have directly investigated the role of prenatal cytokine and chemokine profiles on neurodevelopmental outcomes in humans. In the current study, we characterized mid-gestational serum profiles of 22 cytokines and chemokines in mothers of children with ASD (N=415), developmental delay (DD) without ASD (N=188), and general population (GP) controls (N=428) using a bead-based multiplex technology. The ASD group was further divided into those with intellectual disabilities (developmental/cognitive and adaptive composite score

Published
2017

2. Maternal mid-pregnancy C-reactive protein and risk of autism spectrum disorders: the early markers for autism study.

Author

Zerbo, O, Traglia, M, Yoshida, C, Heuer, LS, Ashwood, P, Delorenze, GN, Hansen, RL, Kharrazi, M, Van de Water, J, Yolken, RH, Weiss, LA, and Croen, LA

Subjects
Humans, C-Reactive Protein, Risk, Case-Control Studies, Mothers, Pregnancy, Pregnancy Trimester, Second, Adult, Infant, California, Female, Male, Young Adult, Autism Spectrum Disorder, Mental Health, Autism, Intellectual and Developmental Disabilities (IDD), Prevention, Brain Disorders, Pediatric, Clinical Research, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Reproductive health and childbirth, Clinical Sciences, Public Health and Health Services, Psychology
Abstract

Maternal pregnancy levels of the inflammatory marker C-reactive protein (CRP) has been previously associated with autism spectrum disorder (ASD) in the offspring. We conducted a population-based nested case-control study with 500 children with ASD, 235 with developmental delay (DD) and 580 general population (GP) controls to further investigate whether elevated CRP during pregnancy increases the risk of ASD. Maternal CRP concentration was measured in archived serum collected during 15-19 weeks of pregnancy and genome-wide single-nucleotide polymorphism (SNP) data were generated. The levels of CRP were compared between ASD vs GP and DD vs GP. The genetic associations with CRP were assessed via linear regression. Maternal CRP levels in mid-pregnancy were lower in mothers of ASD compared with controls. The maternal CRP levels in the upper third and fourth quartiles were associated with a 45 and 44% decreased risk of ASD, respectively. Two SNPs at the CRP locus showed strong association with CRP levels but they were not associated with ASD. No difference was found between maternal CRP levels of DD and controls. The reasons for the lower levels of CRP in mothers of ASD are not known with certainty but may be related to alterations in the immune response to infectious agents. The biological mechanisms underlying this association remain to be clarified.

Published
2016

3. A Genome-Wide Survey of Transgenerational Genetic Effects in Autism

Author

Weiss, Lauren, Tsang, KM, Croen, LA, Torres, AR, Kharrazi, M, Delorenze, GN, Windham, GC, Yoshida, CK, and Zerbo, O

Abstract

Effects of parental genotype or parent-offspring genetic interaction are well established in model organisms for a variety of traits. However, these transgenerational genetic models are rarely studied in humans. We have utilized an autism case-control stud

Published
2013

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