1. The Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting FFR (MEMENTOFFR) Study
- Author
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Antonio Maria Leone, Mariana Faustino, Luís Raposo, José M. de la Torre Hernández, Giuseppe Zimbardo, Eloisa Basile, Cristina Aurigemma, Francesco Burzotta, Giampaolo Niccoli, Antonio Giuseppe Rebuzzi, Nicolas Amabile, Vincent Spagnoli, Ramón López Palop, Sérgio Bravo Baptista, Filippo Crea, Pedro Farto e Abreu, Miren Telleria Arrieta, Italo Porto, Juan Antonio Franco Pelaez, Michel S. Slama, Carlo Trani, Pio Cialdella, Ignacio J. Amat Santos, and Roberto Martín-Reyes
- Subjects
Male ,contrast mediuminduced Pd/Pa ,Contrast Media ,CFFR ,Coronary stenosis ,Fractional flow reserve ,030204 cardiovascular system & hematology ,contrast FFR ,FFR ,03 medical and health sciences ,Hyperaemia ,0302 clinical medicine ,medicine ,Humans ,cFFR ,Contrast FFR ,Contrast mediuminduced Pd/Pa ratio ,Cardiology and Cardiovascular Medicine ,030212 general & internal medicine ,fractional flow reserve ,Aged ,Retrospective Studies ,contrast medium-induced Pd/Pa ration ,business.industry ,Contrast media ,Curve analysis ,Coronary Stenosis ,Limiting ,rati ,Middle Aged ,Hybrid approach ,Fractional Flow Reserve, Myocardial ,Contrast medium ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Functional significance ,Female ,cFFR, contrast FFR, contrast mediuminduced Pd/Pa, rati, FFR, fractional flow reserve ,medicine.symptom ,business ,Nuclear medicine - Abstract
AIMS: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment. The objective was to test the accuracy of Pd/Pa ratio registered during submaximal hyperaemia induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting FFR and comparing it to the performance of resting Pd/Pa in a collaborative registry of 926 patients enrolled in 10 hospitals from four European countries (Italy, Spain, France and Portugal). METHODS AND RESULTS: Resting Pd/Pa, cFFR and FFR were measured in 1,026 coronary stenoses functionally evaluated using commercially available pressure wires. cFFR was obtained after intracoronary injection of contrast medium, while FFR was measured after administration of adenosine. Resting Pd/Pa and cFFR were significantly higher than FFR (0.93±0.05 vs. 0.87±0.08 vs. 0.84±0.08, p
- Published
- 2016