1. Sex related differences in aetiology, severity and quality of life in bronchiectasis: data from the EMBARC, EMBARC-India and Australian bronchiectasis registries
- Author
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Surya Kant Tripathi, Daniel J. Smith, B Archana, Shubham Sharma, Suresh Anantharaj, Srinivas Rajagopala, Antoni Torres, Arjun Khanna, AT Hill, Stuart Elborn, Rajesh Swarnakar, Murali Mohan, Sonali Trivedi, Rachel C. Thomson, Francesco Blasi, Robert Wilson, Katerina Dimakou, Tobias Welte, George D'Souza, Aleemuddin Naveed M, Aditya Jindal, Arjun Padmanabhan, Paul T. King, Honney Sawhney, Rajendra Prasad, Grant W. Waterer, Simon Finch, Girija Nair, Samir Gami, Simone K. Visser, Stefano Aliberti, Anne B. Chang, Gayathri Devi H. Jayadevappa, Sunil Vyas, Babaji Ghewade, Naveen Dutt, Deepak Talwar, Raja Dhar, Charles Haworth, Chien-Li Holmes-Liew, Felix Ringhausen, Megan Crichton, Lata Jayaram, Sundeep Salvi, Amelia Shoemark, Anthony De Soyza, Kripesh R. Sarmah, James D. Chalmers, Kummannoor Venugopal, Lucy Morgan, Eva Polverino, Montse Vendrell, Pieter Goeminne, Sheetu Singh, Padukudru Anand Mahesh, Pierre-Régis Burgel, Kaushik Saha, Lucy D. Burr, Himanshu Garg, Arpan Shah, Enna Salama, Michael Loebinger, Peter G. Middleton, Saurabh Karmakar, Justin Waring, Arti Shah, and Conroy Wong
- Subjects
COPD ,medicine.medical_specialty ,Bronchiectasis ,business.industry ,medicine.medical_treatment ,Disease ,medicine.disease ,Quality of life ,Wheeze ,Internal medicine ,Medicine ,Sputum ,Pulmonary rehabilitation ,medicine.symptom ,business ,Asthma - Abstract
Bronchiectasis is reported to be more frequent in females. There have been no large studies examining the impact of biological sex on disease characteristics, aetiology, severity, quality of life or management. Patients were prospectively enrolled from 2015 -2018 in 3 linked bronchiectasis registries in Australia, Europe and India. Disease information was collected, including quality of life (QoL-B). Analyses were conducted cross-sectionally using baseline data. 13859 patients were included from 29 countries. 57.6% were female. The highest proportion of females were in Australia (70.9%) and lowest in India (43.1%). Male sex was associated with bronchiectasis caused by COPD and TB; while female sex was associated with post-infectious bronchiectasis, asthma, connective tissue disease and NTM. Men had more severe disease as measured by the bronchiectasis severity index, but females more likely to be infected with Pseudomonas aeruginosa. Women had greater disease impact across multiple QoL-B domains including social, emotional and treatment burden domains. Cough and sputum purulence were more severe in women while men most frequently complained of wheeze and breathlessness. Men were significantly less likely to receive evidence based interventions including testing for immunodeficiency and ABPA, long term antibiotic treatment for frequent exacerbators, pulmonary rehabilitation and airway clearance techniques. Conclusion: There are striking sex differences in aetiology, severity, quality of life and treatment in patients with bronchiectasis
- Published
- 2020
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