1. [Immunoglobulins and dysglobulinemias. Introduction and general data].
- Author
-
Peltier AP
- Subjects
- Amino Acid Sequence, Amyloidosis immunology, Animals, Antibody-Producing Cells metabolism, Autoimmune Diseases immunology, B-Lymphocytes metabolism, Cell Membrane metabolism, Clone Cells, Cryoglobulins analysis, Disease Models, Animal, Humans, Immunoglobulin Fragments, Lymphoma immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Myeloma Proteins analysis, Plasma Cells metabolism, Protein Conformation, Rheumatic Diseases immunology, Terminology as Topic, Blood Protein Disorders classification, Dysgammaglobulinemia, Hypergammaglobulinemia classification, Immunoglobulins analysis, Immunoglobulins biosynthesis, Immunoglobulins classification, Immunologic Deficiency Syndromes
- Abstract
The author reviews the present state of knowledge of value in rheumatology concerning serum immunoglobulins, their structure, their cellular biosynthesis, and their relation to membrane immunoglobulins of the B lymphocytes. He then examines the concept of dysglobulinaemia and explains why the terms monoclonal immunoglobulin and monoclonal immunoglobulinopathy are preferable to dysglobulinaemia and paraprotein. The clinical and immunochemical classification of monoclonal immunoglobulins, the problem of amylosis, and the relationship with plasmocytic dyscrasias and with the cryoglobulins are then discussed. Afterwards the pathogeny of these affections is briefly considered.
- Published
- 1974