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In the past decade, the field of Evidence Informed Decision Making (EIDM) has been evolving faster than before. This shows a need for capacity enhancement amongst evidence producers and evidence users in EIDM training. Through the Enhance DELTAS programme, led by the African Institute for Development Policy (AFIDEP), we provided research uptake and policy engagement training, mentorship and webinars to awardees of the Developing Excellence in Leadership, Training and Science (DELTAS) Africa initiative, led by the African Academy of Sciences (AAS). Two workshops were offered to individual early career DELTAS researchers in policy engagement and evidence uptake, referred to as ENHD101, and among research leaders to enhance institutional capacity on policy engagement and evidence uptake, (ENHD102). Overall, over the eight months’ period of training, mentorship and webinars, the programme attracted 31 early career researchers and 20 research leaders. Following the programme, the early career researchers understood the importance of EIDM for better health policies and programmes. In addition, the team appreciated the complexities of the policymaking processes as they developed the policy engagement strategy for their research. The utilisation of the EIDM knowledge was reflected during the mentorship with policy briefs as end product. For research leaders, they appreciated their role in strengthening capacity for EIDM in decision-making spaces. Although during the programme none of the research leaders participated in strengthening capacity for EIDM, the team anticipated improving in the area in the long run. In addition, the research leaders developed and implemented institutional strategies for policy engagement and research uptake through use of social media to influence policymakers. In conclusion, the project supported capacity building of African researchers in EIDM. It was evident that enhancing knowledge and skills on EIDM through an integrated approach to include training, mentorship, and webinars demonstrated enhanced capacity for policy engagement and evidence uptake.