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Background: Physical activity is one of the most important regimens for the treatment of diabetes. Hence, we aimed to examine the association between physical activity knowledge (PAK), knowledge and attitude on diabetes among rural T2DM patients., Objectives: The PAK, knowledge and attitude on diabetes were targeted to evaluate in rural Indian T2DM patients., Methodology: A cross-sectional community-based survey was carried out with eighty-four patients with known T2DM in rural population of India., Results: Among 84 patients, 46 were overweight/obese and 38 patients with normal weight were participated in our study. The odds of smoking were found to be a significant socio-demographic risk factor (OR: 4.42, 95% CI 0.93-20.33 and P<0.001) compared to non-smokers. The PAK categories such as A, B & D had associated with BMI. The OR, 95% CI and P. Value are (5.610, 2.18-14.38 and P<0.001; 1.72, 0.72-4.12 and P 0.030; 2.55, 1.05-6.20 and P 0.047) except in category C. Iilliterates, low annual income, poor knowledge on T2DM and negative attitude, OR (4.50; 12.87; 10.80 and 47.66) were reported disagree or don't know with PAK questionnaire., Conclusion: The results have impact on the design of new education programs will assist in preventing and managing complications related to T2DM., (© 2022 Pelluri R et al.)