1. Outcomes of liver transplantation in the era of modern antiviral therapy for hepatitis C
- Author
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K. Yu. Kokina, Yu. O. Malinovskaya, and Ya. G. Moysyuk
- Subjects
waiting list ,liver transplantation ,antiviral therapy ,direct-acting antivirals ,Surgery ,RD1-811 - Abstract
The emergence of direct-acting antivirals (DAAs) has become the basis for a new potential treatment for chronic hepatitis C (CHC) in patients with decompensated cirrhosis, who previously had no other alternative than liver transplantation (LT). However, optimal timing of antiviral therapy (AVT) remains an issue. Objective: to present a spectrum of clinical outcomes in LT waitlisted patients with HCV-related cirrhosis, who received and did not receive DAA therapy. Materials and methods. Enrolled for the study were 49 waitlisted patients with HCV-related end-stage liver diseases. The patients were divided into 2 groups: Group 1 included 40 patients who received DAA therapy before LT, while Group 2 consisted of 9 patients who did not receive antiviral treatment while on the LT waiting list. Results. The sample was represented in most cases by patients who had MELD/Na score 20, but
- Published
- 2021
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