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Additional file 1: Supplementary Figure 1. Flow cytometric analysis for CD8+CD25+, CD8+CD69+, or CD19+CD25+cells. No significant differences were observed between the DMEM (−), BMMSC-CM, and DPSC-CM groups. n.s.: not significant.

Additional file 2: Supplementary Figure 2. Evaluation of the safety of BMMSC-CM and DPSC-CM. (A) Gross images of BMMSC-CM and DPSC-CM injection twice a week for 2 weeks in 15-week-old NOD mice. (B) Representative H&E-stained histological images of the kidney and pancreas of 15-week-old NOD mice. Bars = 50 μm.

Additional file 3: Supplementary Figure 3. Flow cytometric analysis of CD19+IL-10+ and CD20+CD138+ cells. Each graph on the right side shows the percentages of each B cell subset. The data represent the mean ± standard deviation. n = 6. *p < 0.05.