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1. Additional file 2: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Hoen, Peter, and Roon-Mom, Willeke Van

Abstract

Figure S1. Brain alignment summary. (PDF 116 kb)

Published
2018
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2. Additional file 6: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Peter ‘T Hoen, and Roon-Mom, Willeke Van

Abstract

Figure S4. number of reads and quality of blood RNA sequencing. A Number of reads obtained for each mouse is depicted per time point. RNA sequencing reads were aligned to mouse reference genome build 10 (GRCm38/mm10) using star aligner. B Distribution of reads for blood RNA sequencing indicate that globin reduction was efficient (1st rank gene account for

Published
2018
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3. Additional file 10: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Hoen, Peter, and Roon-Mom, Willeke Van

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Table S2. Lipid classes altered at 4, 12 and 16Â months in SCA3 mice. Only lipid classes with at least one significantly altered unique lipid at any time are shown. (DOCX 14 kb)

Published
2018
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4. Additional file 7: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Hoen, Peter, and Roon-Mom, Willeke Van

Abstract

Figure S5. distribution of metabolite classes and lipid families identified from mass-spec analysis of plasma samples. LC-HRMS analysis of plasma samples led to identification of 148 unique metabolites and 491 lipids. (PDF 88 kb)

Published
2018
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5. Additional file 3: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Hoen, Peter, and Roon-Mom, Willeke Van

Abstract

Figure S2. Brain PCA. (PDF 141 kb)

Published
2018
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6. Additional file 8: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Peter ‘T Hoen, and Roon-Mom, Willeke Van

Abstract

Figure S6. principal component analysis (PCA) of measured metabolites. Individual barcodes of mice are depicted, plasma was obtained for each mouse at 3 time points A) Age is significantly correlated with PC1 (ρ = − 0.586, p

Published
2018
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7. Additional file 1: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Hoen, Peter, and Roon-Mom, Willeke Van

Subjects
3. Good health
Abstract

Table S1. Primers used for qPCR validation of RNA sequencing results. (DOCX 13 kb)

8. Additional file 1: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Author

Toonen, Lodewijk, Overzier, Maurice, Evers, Melvin, Leon, Leticia, Zeeuw, Sander Van Der, Hailiang Mei, Kielbasa, Szymon, Goeman, Jelle, Hettne, Kristina, Olafur Magnusson, Poirel, Marion, Seyer, Alexandre, Hoen, Peter, and Roon-Mom, Willeke Van

Subjects
3. Good health
Abstract

Table S1. Primers used for qPCR validation of RNA sequencing results. (DOCX 13 kb)

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