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Your search keyword '"Sphyris, Nathalie"' showing total 13 results
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13 results on '"Sphyris, Nathalie"'

1. Additional file 8: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
nervous system, human activities
Abstract

Figure S6. KmPlots were generated for several major players of the Wnt signaling pathway using the KmPlotter. Of all the different players, GSK3β was the only gene, the upregulation of which significantly correlated with worse survival in TNBCs. (PDF 322 kb)

Published
2019
Full Text
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2. Additional file 9: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
skin and connective tissue diseases
Abstract

Figure S7. TCGA RPPA data was mined to compare the expression of GSK3β in TNBCs and other types of breast cancer. The analysis of these data revealed a significant increase in the expression of GSK3 in TNBCs as compared to the other types of breast cancer. (PDF 139 kb)

Published
2019
Full Text
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3. Additional file 10: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Abstract

Figure S8. Claudin-low T11 cells were grown in ultra-low attachment plates in mammosphere media for 10 days in the presence of 3 GSK3β inhibitors. The numbers of mammospheres were counted and graphed (n = 3, p values were calculated using Student’s unpaired two-tailed t test). (PDF 94 kb)

Published
2019
Full Text
View/download PDF

4. Additional file 3: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
body regions, nervous system, fungi, 3. Good health
Abstract

Figure S1. The IC50 of the 3 drugs were calculated for the 3 mesenchymal-like cell lines used in this study. (PDF 122â kb)

5. Additional file 5: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
3. Good health
Abstract

Figure S3. GSK3β inhibitor, BIO, is one of the drugs that is capable of inhibiting the sphere forming ability of mesenchymal MDA-MB-231 cells. The drugs that were selected from the screen were used to treat the mammosphere assay. MDA MB 231 reporter cells were grown in ultra-low attachments plates in mammosphere media for 10 days. The number of mammospheres was counted and graphed, and BIO was one of the drugs that decreased the sphere forming ability of the reporter MDA MB 231 cells. The heatmap summarizes the mammosphere data showing that BIO is one of the drugs that decreases the sphere-forming ability of the MDA MB 231 reporter cells. (PDF 141 kb)

6. Additional file 4: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
3. Good health
Abstract

Figure S2. The drugs that were selected from the screen were validated using FACS. The MDA MB 231 reporter cells were treated with all the 11 drugs selected from the screen. Following treatment, the percentage of cells fluorescing red and green were assessed using flow cytometry and plotted for each of the three concentrations to generate the graphs. (PDF 160â kb)

7. Additional file 7: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
fungi, 3. Good health
Abstract

Figure S5. HMLE-vector and HMLE-Snail cells were treated with a dose range of the tested inhibitors, and viability was assessed by MTT assay. Of the drugs that were shortlisted from the screen, BIO was one of the drugs that could selectively inhibit HMLE-Snail cells with mesenchymal phenotype more efficiently as compared to HMLE-vector cells with epithelial phenotype. (PDF 133â kb)

8. Additional file 2: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
body regions, nervous system, fungi, 3. Good health
Abstract

Data S2. Summary of results from the high-throughput screen and the detailed red/green readout for each drug tested in the screen. (PDF 3424â kb)

9. Additional file 3: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
body regions, nervous system, fungi, 3. Good health
Abstract

Figure S1. The IC50 of the 3 drugs were calculated for the 3 mesenchymal-like cell lines used in this study. (PDF 122â kb)

10. Additional file 5: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
3. Good health
Abstract

Figure S3. GSK3β inhibitor, BIO, is one of the drugs that is capable of inhibiting the sphere forming ability of mesenchymal MDA-MB-231 cells. The drugs that were selected from the screen were used to treat the mammosphere assay. MDA MB 231 reporter cells were grown in ultra-low attachments plates in mammosphere media for 10 days. The number of mammospheres was counted and graphed, and BIO was one of the drugs that decreased the sphere forming ability of the reporter MDA MB 231 cells. The heatmap summarizes the mammosphere data showing that BIO is one of the drugs that decreases the sphere-forming ability of the MDA MB 231 reporter cells. (PDF 141 kb)

11. Additional file 2: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
body regions, nervous system, fungi, 3. Good health
Abstract

Data S2. Summary of results from the high-throughput screen and the detailed red/green readout for each drug tested in the screen. (PDF 3424â kb)

12. Additional file 7: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
fungi, 3. Good health
Abstract

Figure S5. HMLE-vector and HMLE-Snail cells were treated with a dose range of the tested inhibitors, and viability was assessed by MTT assay. Of the drugs that were shortlisted from the screen, BIO was one of the drugs that could selectively inhibit HMLE-Snail cells with mesenchymal phenotype more efficiently as compared to HMLE-vector cells with epithelial phenotype. (PDF 133â kb)

13. Additional file 4: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Author

Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Robiya Joseph, Pietila, Mika, Taube, Joseph, Tapasree Sarkar, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Ruli Gao, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Noayuki Miura, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, and Sendurai Mani

Subjects
3. Good health
Abstract

Figure S2. The drugs that were selected from the screen were validated using FACS. The MDA MB 231 reporter cells were treated with all the 11 drugs selected from the screen. Following treatment, the percentage of cells fluorescing red and green were assessed using flow cytometry and plotted for each of the three concentrations to generate the graphs. (PDF 160â kb)

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