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Additional file 4. Comparison of overall survival probability between patients with or without ATRX mutation in non-GC cohorts with ATRX mutation frequency over 10% from TCGA database.

Additional file 2. The differences of ATRX mutation frequency between female and male tumor patients

Additional file 5. Comparison of the TMB and anticancer immunity scores between female and male GC patients. a. Boxplot showing the TMB and anticancer immunity scores between female and male GC patients. Only TMB showed the significantly differences between female and male. b. The differences of TMB between female and male GC patients disappeared when excluding the TMB of ATRX mutant female patients.

Additional file 6. Comparison of the expression of DDR-related core genes between four subgroups. Sub1: female patients with ATRX mutation; Sub2: female patients without ATRX mutation; Sub3: male patients with ATRX mutation; Sub4: male patients without ATRX mutation

Additional file 1. The gene list of ssGSEA

Additional file 3. The impact of ATRX missense mutation on protein structure

Additional file 5. Comparison of the TMB and anticancer immunity scores between female and male GC patients. a. Boxplot showing the TMB and anticancer immunity scores between female and male GC patients. Only TMB showed the significantly differences between female and male. b. The differences of TMB between female and male GC patients disappeared when excluding the TMB of ATRX mutant female patients.

Additional file 4. Comparison of overall survival probability between patients with or without ATRX mutation in non-GC cohorts with ATRX mutation frequency over 10% from TCGA database.

Additional file 6. Comparison of the expression of DDR-related core genes between four subgroups. Sub1: female patients with ATRX mutation; Sub2: female patients without ATRX mutation; Sub3: male patients with ATRX mutation; Sub4: male patients without ATRX mutation

Additional file 2. The differences of ATRX mutation frequency between female and male tumor patients