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Table S1. Primers used in this study. Table S2. The statistical analysis between SOX30 and desmosomal genes. (DOCX 19 kb)

The correlation between ALX4 expression and methylation was analyzed using TCGA data set ( www.cbioportal.com ). A: Cohort1:TCGA, Cell 2015, n = 552;Cohort2. B: TCGA, Provisional 2012, n = 656 Figure S2. Analysis the relationship between ALX4 and Wnt/β-catenin suppression and activation genes in breast cancer using TCGA Database. (A) ALX4 was positively correlated with WIF1 expression (R = 0.503, P = 0.00). (B) ALX4 was negatively correlated with LEF1 expression (R = −0.062, P = 0.03). (C) AXL4 was positively correlated with the expression of the key members of “β-catenin degradation complex” Figure S3. The illustration of full length human β-catenin promoter (−2760 bp to +27 bp) that was cloned into the PGL3-Basic luciferase reporter vector Figure S4. Relationship between ALX4 expression and survival of breast cancer patients retrieved from public datasets( https://genome-cancer.soe.ucsc.edu/proj/site/xena ). (A) Survival analysis using TCGA dataset, the results showed that high expression of ALX4 predicted longer survival time (n = 1080, p = 0.00, 2 group). (B) Survival analysis using TCGA dataset the results showed that high expression of ALX4 predicted longer survival time (n = 1080, p = 0.03, 3 group) Table S1. Primers used in this study. (DOCX 895 kb)