1. Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity
- Author
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Antonia Serrano, Julie A. Chowen, Laura Sánchez-Marín, Marta Torrens, Juan Decara, María Pedraz, Vicente Barrios, Francisco Javier Pavón, Ana Luisa Gavito, Fernando Rodríguez de Fonseca, Nuria García-Marchena, Pablo Romero-Sanchiz, Pedro Araos, Estela Castilla-Ortega, Guillermo Ponce, Jesús Argente, Daniel Silva, Gabriel Rubio, [Garcia-Marchena, Nuria] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Fernando Araos, Pedro] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Sanchez-Marin, Laura] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Pedraz, Maria] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Castilla-Ortega, Estela] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Romero-Sanchiz, Pablo] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Gavito, Ana L.] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Decara, Juan] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Serrano, Antonia] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Rodriguez de Fonseca, Fernando] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Javier Pavon, Francisco] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Garcia-Marchena, Nuria] Univ Complutense Madrid, Fac Psicol, Madrid, Spain, [Silva, Daniel] Univ Complutense Madrid, Fac Psicol, Madrid, Spain, [Rodriguez de Fonseca, Fernando] Univ Complutense Madrid, Fac Psicol, Madrid, Spain, [Barrios, Vicente] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Madrid, Spain, [Chowen, Julie A.] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Madrid, Spain, [Argente, Jesus] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Madrid, Spain, [Barrios, Vicente] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain, [Chowen, Julie A.] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain, [Argente, Jesus] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain, [Barrios, Vicente] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Chowen, Julie A.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Argente, Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Ponce, Guillermo] Hosp Univ 12 Octubre, Serv Psiquiatria, Madrid, Spain, [Rubio, Gabriel] Hosp Univ 12 Octubre, Serv Psiquiatria, Madrid, Spain, [Torrens, Marta] Inst Neuropsiquiatria & Addicc INAD, Barcelona, Spain, [Torrens, Marta] Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Torrens, Marta] Univ Autonoma Barcelona, Dept Psychiat, Barcelona, Spain, RETICS Red de Trastornos Adictivos - Instituto de Salud Carlos III (ISC-III), European Regional Development Funds-European Union (ERDF-EU), Ministerio de Economia y Competitividad, ISC-III, Ministerio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas, Consejeria de Economia, Innovacion y Ciencia, Junta de Andalucia, ERDF-EU, Consejeria de Salud y Bienestar Social, Junta de Andalucia, [García-Marchena,N, Araos,PF, Sánchez-Marín,L, Pedraz,M, Castilla-Ortega,E, Romero-Sanchiz,P, Gavito,AL, Decara,J, Serano,A, Rodríguez de Fonseca,F, Pavón,FJ] Unidad Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain. [García-Marchena,N, Silva,D, Rodríguez de Fonseca,F] Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Barrios,V, Chowen,JA, Argente,J] Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain. CIBER Fisiopatología de la obesidad y nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. [Ponce,G] Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Madrid, Spain, [Torrens,M] Institut de Neuropsiquiatria i Addiccions (INAD), Barcelona, Spain. Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain,. Department of Psychiatry, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., The present study has been supported by RETICS Red deTrastornos Adictivos (RD12/0028/0021) funded by Instituto de Salud Carlos III (ISC-III) and European Regional Development Funds-European Union (ERDF-EU), research projects funded by Ministerio de Economía y Competitividad and ISC-III (PI13/02261 and PI16/01953), Ministerio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas (049/2009 and 049/2013), Consejería de Economía, Innovación y Ciencia, Junta de Andalucía and ERDF-EU (CTS-433), and and Consejería de Salud y Bienestar Social, Junta de Andalucía (PI0228-2013 and PI0823-2012). AS and FP hold Miguel Servet research contracts funded by ISC-III and ERDF-EU (CP14/00173 and CP14/00212, respectively). PR-S holds a 'Río Hortega' research contract funded by ISC-III and ERDF-EU (CM13/0115). EC-O holds a 'Sara Borrell' research contract funded by ISC-III and ERDF-EU (CD12/00455).
- Subjects
0301 basic medicine ,Eotaxin ,Aspartato aminotransferasas ,Chemokine ,Pathology ,Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings] ,Anatomy::Digestive System::Liver [Medical Subject Headings] ,PRISM ,Etanol ,Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders [Medical Subject Headings] ,Trastornos del humor ,Quimiocina CXCL12 ,Co-morbidity ,Cocaine users ,Anxiety ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Aminoacyltransferases::gamma-Glutamyltransferase [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders [Medical Subject Headings] ,Alcohol use disorder ,0302 clinical medicine ,Psychiatry and Psychology::Behavioral Disciplines and Activities::Behavioral Sciences::Psychiatry [Medical Subject Headings] ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity [Medical Subject Headings] ,Medicine ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar [Medical Subject Headings] ,Quimiocina CX3CL1 ,Masculino ,Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CC::Chemokine CCL11 [Medical Subject Headings] ,Voluntarios sanos ,Health Care::Population Characteristics::Demography::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings] ,CCL11 ,Original Research ,Persons::Persons::Patients::Outpatients [Medical Subject Headings] ,Psychiatry ,Hígado ,biology ,Pacientes ambulatorios ,Femenino ,Alcoholisme -- Tractament ,Brain ,Comorbilidad ,Humanos ,Psychiatry and Mental health ,psychiatric comorbidity ,Trastornos relacionados con sustancias ,Cytokines ,Sex ,Microglia ,outpatient setting ,medicine.symptom ,Fenotipo ,medicine.medical_specialty ,Cells ,Psychiatric comorbidity ,Check Tags::Male [Medical Subject Headings] ,Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CX3C::Chemokine CX3CL1 [Medical Subject Headings] ,Conducta adictiva ,alcohol use disorder ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Impulsive Behavior::Compulsive Behavior::Behavior, Addictive [Medical Subject Headings] ,Increased serum-levels ,03 medical and health sciences ,Células del estroma ,Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CXC::Chemokine CXCL12 [Medical Subject Headings] ,Internal medicine ,Persons::Persons::Volunteers::Healthy Volunteers [Medical Subject Headings] ,mental disorders ,sex ,Interleukin 8 ,eotaxin ,CX3CL1 ,Psiquiatría ,Anatomy::Cells::Connective Tissue Cells::Stromal Cells [Medical Subject Headings] ,Outpatient setting ,Ethanol ,business.industry ,Ratas wistar ,chemokine ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases::Aspartate Aminotransferases [Medical Subject Headings] ,medicine.disease ,Psychiatry and Psychology::Mental Disorders::Mood Disorders [Medical Subject Headings] ,Comorbidity ,Quimiocina CCL11 ,Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol [Medical Subject Headings] ,030104 developmental biology ,Endocrinology ,Check Tags::Female [Medical Subject Headings] ,Mood disorders ,biology.protein ,Trastornos relacionados con alcohol ,gamma-glutamiltransferasa ,Prevalencia ,business ,030217 neurology & neurosurgery ,Liver-disease - Abstract
Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To this end, 85 abstinent subjects with AUD from an outpatient setting and 55 healthy subjects were evaluated for substance and mental disorders. Plasma samples were obtained to quantify chemokine concentrations [C-C motif (CC), C-X-C motif (CXC), and C-X3-C motif (CX3C) chemokines]. Abstinent AUD patients displayed a high prevalence of comorbid mental disorders (72%) and other substance use disorders (45%). Plasma concentrations of chemokines CXCL12/stromal cell-derived factor-1 (p
- Published
- 2017