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1. Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation.

Author

Toso C, Edgar R, Pawlick R, Emamaullee J, Merani S, Dinyari P, Mueller TF, Shapiro AM, and Anderson CC

Subjects
Alemtuzumab, Antibodies, Monoclonal, Humanized, Antilymphocyte Serum, Daclizumab, Female, Flow Cytometry, Humans, Male, Middle Aged, Prospective Studies, Antibodies, Monoclonal pharmacology, Antibodies, Neoplasm pharmacology, Immunoglobulin G pharmacology, Immunosuppressive Agents pharmacology, Islets of Langerhans Transplantation immunology, Lymphocyte Subsets drug effects, Lymphocyte Subsets immunology
Abstract

This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post-transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associated with an early (within 1 month) and transient (up to 6 months) increase in the frequency of CD3(+) CD4(+) Foxp3(+) T cells, while daclizumab induced a near complete loss of these cells (P

Published
2009
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