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Your search keyword '"Alexandra Barbouti"' showing total 2 results
Start Over Author "Alexandra Barbouti" Publisher frontiers media s.a.
2 results on '"Alexandra Barbouti"'

1. Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract

Author

Evagelia Spanou, Polyxeni Kalisperati, Ioannis S. Pateras, Alexandros Papalampros, Alexandra Barbouti, Athanasios G. Tzioufas, Athanassios Kotsinas, and Stavros Sougioultzis

Subjects
toll-like receptors (TLRs), nod-like receptors (NLRs), DNA damage response (DDR), single nucleotide polymorphism (SNP), mutation, inflammation and tumorigenesis, Genetics, QH426-470
Abstract

The fundamental role of human Toll-like receptors (TLRs) and NOD-like receptors (NLRs), the two most studied pathogen recognition receptors (PRRs), is the protection against pathogens and excessive tissue injury. Recent evidence supports the association between TLR/NLR gene mutations and susceptibility to inflammatory, autoimmune, and malignant diseases. PRRs also interfere with several cellular processes, such as cell growth, apoptosis, cell proliferation, differentiation, autophagy, angiogenesis, cell motility and migration, and DNA repair mechanisms. We briefly review the impact of TLR4 and NOD1/NOD2 and their genetic variability in the process of inflammation, tumorigenesis and DNA repair, focusing in the gastrointestinal tract. We also review the available data on new therapeutic strategies utilizing TLR/NLR agonists and antagonists for cancer, allergic diseases, viral infections and vaccine development against both infectious diseases and cancer.

Published
2017
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2. Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract

Author

Athanasios G. Tzioufas, Polyxeni Kalisperati, Evagelia Spanou, Alexandros Papalampros, Alexandra Barbouti, Athanassios Kotsinas, Stavros Sougioultzis, and Ioannis S. Pateras

Subjects
0301 basic medicine, nod-like receptors (NLRs), lcsh:QH426-470, DNA damage, DNA repair, inflammation and tumorigenesis, Inflammation, Review, Biology, Gene mutation, medicine.disease_cause, DNA damage response (DDR), 03 medical and health sciences, 0302 clinical medicine, single nucleotide polymorphism (SNP), NOD2, medicine, Genetics, Receptor, Genetics (clinical), Mutation, lcsh:Genetics, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, Molecular Medicine, toll-like receptors (TLRs), medicine.symptom, mutation, Carcinogenesis
Abstract

The fundamental role of human Toll-like receptors (TLRs) and NOD-like receptors (NLRs), the two most studied pathogen recognition receptors (PRRs), is the protection against pathogens and excessive tissue injury. Recent evidence supports the association between TLR / NLR gene mutations and susceptibility to inflammatory, autoimmune and malignant diseases. PRRs also interfere with several cellular processes, such as cell growth, apoptosis, cell proliferation, differentiation, autophagy, angiogenesis, cell motility and migration, and DNA repair mechanisms. We briefly review the impact of TLR4 and NOD1/NOD2 and their genetic variability in the process of inflammation, tumorigenesis and DNA repair, focusing in the gastrointestinal tract. We also review the available data on new therapeutic strategies utilizing TLR /NLR agonists and antagonists for cancer, allergic diseases, viral infections and vaccine development against both infectious diseases and cancer.

Published
2017
Full Text
View/download PDF

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