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Your search keyword '"Bret Rust"' showing total 2 results
Start Over Author "Bret Rust" Publisher frontiers media s.a.
2 results on '"Bret Rust"'

1. Initial implicit association between whole grains and taste does not predict consumption of whole grains in low-whole grain consumers: a pilot randomized controlled trial

Author

Angela De Leon, Dustin J. Burnett, Bret Rust, Marika Lyly, and Nancy L. Keim

Subjects
implicit association, Implicit Association Test, mere exposure, taste, whole grain consumption, whole grains, Nutrition. Foods and food supply, TX341-641
Abstract

BackgroundHealth benefits of whole grain (WG) consumption are well documented. Current Dietary Guidelines for Americans recommend at least half of total grains consumed be WG; however, Americans consume less than one serving of WG per day. Inferior taste of whole grain products as compared with refined grain products has been reported as one of the main barriers to acceptability and consumption of whole grains. In this pilot study, we aimed to determine if mere exposure to WG foods in self-reported low WG consumers would improve their implicit associations between WG and pleasant taste.MethodsHealthy adults (n=45) were provided a variety of WG or refined grain (RG) products for home use for 6 weeks. Intake was measured by calculating disappearance and verified by a daily log. At the beginning and end of the intervention, we administered an Implicit Association Test (IAT), a computer test designed to measure indirectly the strength of association between pairs of concepts: (a) two contrasted target categories (WG and RG food images) and (b) two contrasted attribute categories (words relating to pleasant or unpleasant taste) via a classification task. Response time was used to calculate IAT D scores, indicating the strength of implicit associations between WG and RG and positive or negative taste.ResultsANCOVA showed that average D scores at the end of the study shifted significantly toward a positive implicit association between WG and good taste (p

Published
2024
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2. Mammary Tumorigenesis and Metabolome in Male Adipose Specific Monocyte Chemotactic Protein-1 Deficient MMTV-PyMT Mice Fed a High-Fat Diet

Author

Michael R. Bukowski, Matthew J. Picklo, Bret Rust, Sneha Sundaram, and Lin Yan

Subjects
Cancer Research, medicine.medical_specialty, mice, Adipokine, Adipose tissue, Biology, CCL2, male, Internal medicine, medicine, Metabolome, adipose MCP-1, MMTV-PyMT, RC254-282, Original Research, Monocyte, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Obesity, plasma metabolome, medicine.anatomical_structure, Endocrinology, Oncology, Tumor progression, Male breast cancer, diet
Abstract

Male breast cancer, while uncommon, is a highly malignant disease. Monocyte chemotactic protein-1 (MCP-1) is an adipokine; its concentration in adipose tissue is elevated in obesity. This study tested the hypothesis that adipose-derived MCP-1 contributes to male breast cancer. In a 2x2 design, male MMTV-PyMT mice with or without adipose-specific Mcp-1 knockout [designated as Mcp-1-/- or wild-type (WT)] were fed the AIN93G standard diet or a high-fat diet (HFD) for 25 weeks. Mcp-1-/- mice had lower adipose Mcp-1 expression than WT mice. Adipose Mcp-1 deficiency reduced plasma concentrations of MCP-1 in mice fed the HFD compared to their WT counterparts. Mcp-1-/- mice had a longer tumor latency (25.2 weeks vs. 18.0 weeks) and lower tumor incidence (19% vs. 56%), tumor progression (2317% vs. 4792%), and tumor weight (0.23 g vs. 0.64 g) than WT mice. Plasma metabolomics analysis identified 56 metabolites that differed among the four dietary groups, including 22 differed between Mcp-1-/- and WT mice. Pathway and network analyses along with discriminant analysis showed that pathways of amino acid and carbohydrate metabolisms are the most disturbed in MMTV-PyMT mice. In conclusion, adipose-derived MCP-1 contributes to mammary tumorigenesis in male MMTV-PyMT. The potential involvement of adipose-derived MCP-1 in metabolomics warrants further investigation on its role in causal relationships between cancer metabolism and mammary tumorigenesis in this male MMTV-PyMT model.

Published
2021

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