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In engineering practice, engineers generally treated tuff as a lumpy material with a poorly defined laminated structure and a rock group that was not susceptible to slide failure. Most studies of tuff landslides had focused on small clastic landslides in shallow strata with weathering boundaries and lithologic interfaces as slip surfaces. This paper takes a large-scale, deep-seated tuff landslide on the southeast coast of China as the research project. We used borehole TV imaging and exploration tunnels to confirm the material composition and structural characteristics of the tuff stratum and used exploration tunnels to expose the slip soil directly. Microscopic identification, mineralogical composition analysis, zircon U-Pb isotope dating, and Hf isotope analysis of slip soils collected from the exploration tunnels elucidated the geologic background and genesis of the large-scale deep-seated landslides in the tuff stratum. It was found that the formation of a tuff stratum in the landslide area was caused by multi-volcanic orogeny and multi-phase tectonics. The timing of the melting of the original magma from these volcanic events also differs. During these intervals between eruptions, deposition occurred, and this sedimentary material formed the slip soil.

Anticardiolipin antibody (aCL), an important characterization of antiphospholipid syndrome, shows an intense association with vascular endothelial injury. Hyperoside is a flavonoid extracted from medicinal plants traditionally used in Chinese medicines, displaying anti-inflammatory, anti-cancer, and anti-oxidative properties in various diseases. Recent studies have shifted the focus on the protective effects of hyperoside on vascular endothelial injury. However, little is known about the mechanisms involved. In the present study, we investigated the effect of hyperoside on aCL-induced injury of human umbilical vein endothelial cells (HUVECs) in vitro. Our data illustrated that aCL induced HUVEC injury via inhibiting autophagy. Hyperoside reduced aCL-induced secretion of proinflammatory cytokines IL-1β and IL-8 and endothelial adhesion cytokines TF, ICAM1, and VCAM1 in HUVECs. Additionally, hyperoside activated autophagy and suppressed the mTOR/S6K and TLR4/Myd88/NF-κB signaling transduction pathways in aCL-induced HUVECs. To the best of our knowledge, this is the first study to investigate the effect of hyperoside on aCL-induced injury, as well as offer insights into the involved mechanisms, which is of great significance for the treatment of antiphospholipid syndrome.

MADS-domain proteins are important transcription factors involved in many aspects of plant reproductive development. In this study, a MADS-box gene, Glycine max AGAMOUS-LIKE1 (GmAGL1), was isolated from soybean flower. The transcript of GmAGL1 was expressed in flowers and pods of different stages in soybean and was highly expressed in carpels. GmAGL1 is a nucleus-localized transcription factor and can interact directly with SEP-like proteins in soybean flowers. Ectopic overexpression of GmAGL1 resulted in the absence of petals in Arabidopsis. Moreover, morphological changes in the valves were observed in 35S:GmAGL1 Arabidopsis fruits that dehisced before the seeds reached full maturity. GmAGL1 was found to be sufficient to activate the expression of Arabidopsis ALC, IND, STK, SEP1, and SEP3. Therefore, our data suggest that GmAGL1 may play important roles in both floral organ identity and fruit dehiscence. [ABSTRACT FROM AUTHOR]