1. Reduced Risk of Atrial Fibrillation Following Cholecystectomy: A Nationwide Population-Based Study
- Author
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Tung Ching Ho, Yu-Ching Chen, Che-Chen Lin, Hsu-Chih Tai, Cheng-Yu Wei, Yung-Hsiang Yeh, and Chung Y. Hsu
- Subjects
atrial fibrillation ,risk factors ,gallstone disease ,cholelithiasis ,cholecystectomy ,prevention ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Gallstone disease (GD) is associated with a high risk of cardiovascular disease. However, it is unknown whether GD contributes to atrial fibrillation (AF). We aimed to investigate the association between GD and AF.Methods: We performed a population-based cohort study using data from the Taiwan National Health Insurance Research Database between 2001 and 2011. A GD cohort of 230,076 patients was compared with a control cohort consisting of an equal number of patients matched for age, sex, cardiovascular and gastrointestinal comorbidities.Results: In total, 5,992 (49.8/10,000 person-years) patients with GD and 5,804 (44.5/10,000 person-years) controls developed AF. GD increased AF risk with a hazard ratio (HR) of 1.20 [95% confidence interval (CI), 1.16–1.25]. In patients with GD but without cholecystectomy, the HR of AF reached 1.57 (95% CI = 1.50–1.63). After cholecystectomy, the HR of AF significantly decreased to 0.85 (95% CI = 0.81–0.90). Among the three age groups with GD (
- Published
- 2021
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