1. An age-and sex-matched postoperative therapy should be required in thyroid papillary carcinoma
- Author
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Caigu Yan, Jinjin Sun, Xianghui He, and Lanning Jia
- Subjects
papillary thyroid carcinoma ,lymph node metastasis ,TSH ,131I ,SLC5A5 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background and purposeThyroid papillary carcinoma (PTC) had a high possibility of recurrence after surgery, and thyroid stimulating hormone (TSH) suppression and radioactive iodine (131I) were used for postoperative therapy. This study explored the potential mechanism of lymph node metastasis (LNM) and aimed to develop differentiated treatments for PTC.MethodThis study explored the risk factors of lymph node metastasis in PTC by analyzing the clinical information of 2073 cases. The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) and the Gene Expression Omnibus (GEO) databases of gene expression were analyzed to identify the interrelationships between gene expression to phenotype.ResultsAnalyzing clinical data, we found that male gender, younger age, larger tumor size, and extra-thyroidal extension (ETE) were risk significant risk factors for lymph node metastasis(P0.05), and TSH levels were observed to be higher in females(P
- Published
- 2024
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