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Your search keyword '"Kelly A. Wong"' showing total 2 results
Start Over Author "Kelly A. Wong" Publisher frontiers media s.a.
2 results on '"Kelly A. Wong"'

1. Associations of comorbid depression with cardiovascular-renal events and all-cause mortality accounting for patient reported outcomes in individuals with type 2 diabetes: a 6-year prospective analysis of the Hong Kong Diabetes Register

Author

Yiu-Lam Yeung, Ka-Long Lee, Eric SH. Lau, Tsun-Fung Yung, Aimin Yang, Hongjiang Wu, Kelly TC. Wong, Alice PS. Kong, Elaine YK. Chow, Ronald CW. Ma, Theresa Yeung, Kit-man Loo, Risa Ozaki, Andrea OY. Luk, Juliana NM. Lui, and Juliana CN. Chan

Subjects
depression, cardiovascular-renal events, mortality, patient reported outcomes, health related quality of life, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

BackgroundPsychosocial status and patient reported outcomes (PRO) [depression and health-related quality-of-life (HRQoL)] are major health determinants. We investigated the association between depression and clinical outcomes in Chinese patients with type 2 diabetes (T2D), adjusted for PRO.MethodsUsing prospective data from Hong Kong Diabetes Register (2013-2019), we estimated the hazard-ratio (HR, 95%CI) of depression (validated Patient Health Questionnaire 9 (PHQ-9) score≥7) with incident cardiovascular disease (CVD), ischemic heart disease (IHD), chronic kidney disease (CKD: eGFR

Published
2024
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2. Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum

Author

Kelly L.L. Wong, George J. Augustine, Aditya Nair, Lee Kong Chian School of Medicine (LKCMedicine), and Institute of Molecular and Cell Biology, A*STAR

Subjects
Cognitive Neuroscience, Dopamine, Neuroscience (miscellaneous), Neurosciences. Biological psychiatry. Neuropsychiatry, Substantia nigra, Claustrum, Review, Biology, Serotonergic, Cellular and Molecular Neuroscience, medicine, Medicine [Science], Neurons, Basal forebrain, Raphe, Ventral Tegmental Area, Sensory Systems, Neuromodulation (medicine), Acetylcholine, acetylcholine, serotonin, Ventral tegmental area, Substantia Nigra, medicine.anatomical_structure, claustrum, neuromodulation, Neuroscience, RC321-571, medicine.drug
Abstract

The claustrum is a thin sheet of neurons that is densely connected to many cortical regions and has been implicated in numerous high-order brain functions. Such brain functions arise from brain states that are influenced by neuromodulatory pathways from the cholinergic basal forebrain, dopaminergic substantia nigra and ventral tegmental area, and serotonergic raphe. Recent revelations that the claustrum receives dense input from these structures have inspired investigation of state-dependent control of the claustrum. Here, we review neuromodulation in the claustrum—from anatomical connectivity to behavioral manipulations—to inform future analyses of claustral function. Ministry of Education (MOE) Published version This work was supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2017-T3-1-002).

Published
2021

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