Search

Background and aimsThe left atrial function index (LAFI) is an index that combines the left atrial emptying fraction, adjusted left atrial volume and stroke volume. The prognostic value of LAFI in acute myocardial infarction (AMI) patients treated with percutaneous coronary intervention (PCI) is unknown. This study aims to determine whether LAFI predicts prognosis in AMI patients treated with PCI.MethodsPatients with newly diagnosed AMI who were treated with PCI at Hunan Provincial People's Hospital from March 2020 to October 2021 were prospectively enrolled. All patients underwent transthoracic echocardiography (TTE) at baseline and follow-up. The endpoint events included rehospitalization due to unstable angina, nonfatal myocardial infarction, rehospitalization due to heart failure and cardiovascular death.ResultsA total of 368 patients with AMI (92 women; mean age, 61.45 ± 11.91 years) were studied with a median follow-up of 14 ± 6.58 months. Sixty-nine patients had endpoint events. Patients who presented with events had a significantly lower LAFI than patients without events (34.25 ± 12.86 vs. 48.38 ± 19.42, P 40.17 cm/ml/m2 (HR = 8.53 [95% CI: 4.74; 15.35]; P

The present study aims to explore the role of nuclear energy production in aiding the sustainable economic growth of Chine by exploring the underlying causal relationship between reducing Carbon-di-oxide emissions and nuclear energy production. The study also aims to explore the relationship between economic growth and nuclear energy production in the Chinese context. Besides that, the present research also provides evidence in favor of nuclear energy in terms of controlling the overall emissions target of the Chinese government. The main aim of the present research is to investigate the effect of the use of nuclear energy on the Chinese Carbon-di-oxide emissions and its contribution to the growth of Chinese Gross Domestic Product by utilizing the data from 1992 to 2020. Using a modified Granger causality test, the present research identified one-way causation between the usage of nuclear energy and emissions of Carbon-di-oxide. Based on the research findings, it can be argued that by utilizing nuclear power, China can control the emissions of greenhouse gasses, to meet the global emission targets.

The urban transit system is considered the backbone of any society as it heavily depends on economic progress. The railway transit system is crucial for any urban transit system. Based on this notion, the present research explores the industrial agglomeration in China’s prefecture-level and cities from 2010 to 2020. The research analyses the processes of urban rail transit building, industrial agglomeration, and labor agglomeration due to the railway’s transit network development. The findings are summarized in three main points; first, the agglomeration of the labor force is positively affected by the construction of urban rail transit infrastructure. Secondly, the development of railways infrastructure stimulates the agglomeration of manufacturing industries in and near urban population centers leading to the development of services industries. Third, the development and integration of railways networks with other transportation networks also optimize the allocation of capital in these areas as well. In the present research Preacher and Hayes, Behavior research methods, 2008, 40 (3), 879–891 methodology has been applied to determine the relationship between the development of railways transit system and concentration of industries, by taking into account the mediating effects of labor agglomeration. The development of railways network tends to bring economic and industrial development to these regions resulting in overall social development.

Excess dietary fructose intake is a major public health concern due to its deleterious effect to cause various metabolic and cardiovascular diseases. However, little is known about the effects of high-fructose consumption during pregnancy on offspring metabolic health in adulthood. Here, we show that maternal consumption of 20% (w/v) fructose water during pregnancy does not alter the metabolic balance of offspring with a chow diet, but predisposes them to obesity, fatty liver, and insulin resistance when challenged by a high-fat diet. Mechanistically, diet-induced brown fat reprogramming and global energy expenditure in offspring of fructose-fed dams are impaired. RNA-seq analysis of the fetal brown fat tissue reveals that the myogenic pathway is predominantly upregulated in the fructose-treated group. Meanwhile, circulating fructose level is found to be significantly elevated in both fructose-fed dams and their fetuses. Importantly fructose gavage also acutely activates the myogenic program in mice brown fat. Together, our data suggest that maternal high-fructose intake impairs fetal brown fat development, resultantly attenuates diet-induced thermogenesis and causes metabolic disorders in adult offspring probably through inducing myogenic signature in brown fat at the fetal stage.

Liver is an important organ for fat metabolism. Excessive intake of a high-fat/energy diet is a major cause of hepatic steatosis and its complications such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Supplementation with lycopene, a natural compound, is effective in lowering triglyceride levels in the liver, although the underlying mechanism at the translational level is unclear. In this study, mice were fed a high-fat diet (HFD) to induce hepatic steatosis and treated with or without lycopene. Translation omics and transcriptome sequencing were performed on the liver to explore the regulatory mechanism of lycopene in liver steatosis induced by HFD, and identify differentially expressed genes (DEGs). We identified 1,358 DEGs at the translational level. Through transcriptomics and translatomics joint analysis, we narrowed the range of functional genes to 112 DEGs and found that lycopene may affect lipid metabolism by regulating the expression of LPIN1 at the transcriptional and translational levels. This study provides a powerful tool for translatome and transcriptome integration and a new strategy for the screening of candidate genes.