1. Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients
- Author
-
Qirui Jiang, Yuan Guo, Tianmi Yang, Shirong Li, Yanbing Hou, Junyu Lin, Yi Xiao, Ruwei Ou, Qianqian Wei, and Huifang Shang
- Subjects
amyotrophic lateral sclerosis ,cystatin C ,prognosis ,clinical ,biomarker ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
BackgroundCystatin C (CysC) levels in amyotrophic lateral sclerosis (ALS) have been found changes, however, the associations between serum CysC levels and the progression and survival of ALS remain largely unknown.MethodsA total of 1,086 ALS patients and 1,026 sex-age matched healthy controls (HCs) were enrolled in this study. Serum CysC, other renal function, and metabolic parameters were measured. Correlation analysis and binary logistic regression were used to explore the factors related to serum CysC. Kaplan–Meier curve and Cox regression model were used for survival analysis.ResultsCysC levels were significantly higher in ALS patients compared to HCs (0.94 vs. 0.85 mg/L, p
- Published
- 2024
- Full Text
- View/download PDF