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An ecological safety pattern is the basic guarantee for pollution control, ecological environmental protection, economic construction, and sustainable social development, and is an important means of integrated and coordinated development, protection, and governance. This study proposes a research method to identify ecological source sites based on the evaluation of the importance of ecosystem services and ecological sensitivity, and to identify ecological corridors using the minimum cumulative resistance model. The empirical analysis was carried out in Yangxin County, Hubei Province, as an example. The results show that the study area has 16 key corridors and 29 potential corridors, a total of 45 ecological corridors, with a total length of 452 km. In addition, these ecological corridors present a network-like intertwined distribution, connecting various ecological source sites and ensuring the connectivity between ecological source sites, while the well-developed water source sites in the study area provide excellent ecosystem service functions such as water containment for the area.

Breast cancer is the most common malignant tumor in adult women. Its common metastatic sites are lymph nodes, bones, lungs, the liver, and the brain. It is so rare for a patient with breast cancer to have metastases of the gastrointestinal tract, peritoneum, and ovary at the same time that the clinical reporting rate is low. We present a case of a 61-year-old woman who underwent right mastectomy and chemoradiotherapy 3 years ago because of mixed invasive ductal-lobular breast cancer. This time, she came to the hospital due to the symptom of stomach discomfort for 2 weeks. The gastroscopy biopsy result showed gastric metastasis from breast cancer. Then, 18F-FDG imaging and 68Ga-FAPI PET/CT imaging were performed for further diagnosis; 68Ga-FAPI PET/CT demonstrated a significantly elevated FAPI activity in the thickened gastric wall, peritoneum, and bilateral adnexal areas, which was superior to that of 18F-FDG. Finally, a biopsy of suspicious lesions was taken for pathological and histochemical examination, which confirmed that, in addition to the gastric metastasis, the peritoneum and bilateral ovaries were all consistent with metastatic breast cancer.

Breast cancer is the most common malignant tumor in adult women. Its common metastatic sites are lymph nodes, bones, lungs, the liver, and the brain. It is so rare for a patient with breast cancer to have metastases of the gastrointestinal tract, peritoneum, and ovary at the same time that the clinical reporting rate is low. We present a case of a 61-year-old woman who underwent right mastectomy and chemoradiotherapy 3 years ago because of mixed invasive ductal-lobular breast cancer. This time, she came to the hospital due to the symptom of stomach discomfort for 2 weeks. The gastroscopy biopsy result showed gastric metastasis from breast cancer. Then, 18F-FDG imaging and 68Ga-FAPI PET/CT imaging were performed for further diagnosis; 68Ga-FAPI PET/CT demonstrated a significantly elevated FAPI activity in the thickened gastric wall, peritoneum, and bilateral adnexal areas, which was superior to that of 18F-FDG. Finally, a biopsy of suspicious lesions was taken for pathological and histochemical examination, which confirmed that, in addition to the gastric metastasis, the peritoneum and bilateral ovaries were all consistent with metastatic breast cancer. [ABSTRACT FROM AUTHOR]

In boxing, the wrong training methods can easily cause physical injury, so many sports protective clothing will use new materials to reduce the impact of boxing training. The aim of this paper is to design a boxing suit based on graphene composite fiber seamless knitted fabric, so as to reduce the injury of boxers during training. In this paper, the head yarn, inner yarn and knitting structure of graphene composite fiber seamless knitted fabrics are discussed, and nine kinds of fabrics are determined by orthogonal matrix method; then, a comprehensive evaluation of the wear resistance of fabrics was proposed based on sequence entropy weight technology, and the ideal solution similarity (TOPSIS) method was used to calculate the wear resistance; finally, this paper designed the boxing protective suit according to the best combination of performance. The experimental results in this paper showed that the veil of sample No. 7 is 70D/48F graphene nylon, the inner yarn is 30D graphene spandex/70D graphene nylon covered yarn, and the fabric with the knitted structure of 1 + 3 false rib has the best comprehensive performance and the highest relative proximity, reaching 0.862. The actual wearing test proves that the comfort of anti-impact boxing suit is slightly better than that of ordinary boxing suit. The clothing designed in this paper has good anti-impact effect. Therefore, on the whole, the boxing suit with graphene composite fiber seamless knitted fabric has good protective effect and can be used for boxing training.

Hepatocellular carcinoma (HCC) patients are mostly diagnosed at an advanced stage, resulting in systemic therapy and poor prognosis. Therefore, the identification of a novel treatment target for HCC is important. B-cell receptor-associated protein 31 (BAP31) has been identified as a cancer/testis antigen; however, BAP31 function and mechanism of action in HCC remain unclear. In this study, BAP31 was demonstrated to be upregulated in HCC and correlated with the clinical stage. BAP31 overexpression promoted HCC cell proliferation and colony formation in vitro and tumor growth in vivo. RNA-sequence (RNA-seq) analysis demonstrated that serpin family E member 2 (SERPINE2) was downregulated in BAP31-knockdown HCC cells. Coimmunoprecipitation and immunofluorescence assays demonstrated that BAP31 directly binds to SERPINE2. The inhibition of SERPINE2 significantly decreased the BAP31-induced cell proliferation and colony formation of HCC cells and phosphorylation of Erk1/2 and p38. Moreover, multiplex immunohistochemistry staining of the HCC tissue microarray showed positive associations between the expression levels of BAP31, SERPINE2, its downstream gene LRP1, and a tumor proliferation marker, Ki-67. The administration of anti-BAP31 antibody significantly inhibited HCC cell xenograft tumor growth in vivo. Thus, these findings suggest that BAP31 promotes tumor cell proliferation by stabilizing SERPINE2 and can serve as a promising candidate therapeutic target for HCC.