1. Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity
- Author
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Snežana Smederevac, Lissette Delgado-Cruzata, Dušanka Mitrović, Bojana M. Dinić, Toni-Ann T. Bravo, Maria Delgado, Vojislava Bugarski Ignjatović, Selka Sadiković, Ilija Milovanović, Nataša Vučinić, Bojan Branovački, Mechthild Prinz, Zoran Budimlija, Jelena Kušić‐Tišma, and Željka Nikolašević
- Subjects
Genetics ,Molecular Medicine ,Genetics (clinical) - Abstract
Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors.
- Published
- 2023
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