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9 results on '"Cao, Jiawei"'

6. Identification of floR Variants Associated With a Novel Tn4371-Like Integrative and Conjugative Element in Clinical Pseudomonas aeruginosa Isolates

Author

Qian, Changrui, primary, Liu, Hongmao, additional, Cao, Jiawei, additional, Ji, Yongan, additional, Lu, Wei, additional, Lu, Junwan, additional, Li, Aifang, additional, Zhu, Xinyi, additional, Shen, Kai, additional, Xu, Haili, additional, Chen, Qianqian, additional, Zhou, Wangxiao, additional, Lu, Hongyun, additional, Lin, Hailong, additional, Zhang, Xueya, additional, Li, Qiaoling, additional, Lin, Xi, additional, Li, Kewei, additional, Xu, Teng, additional, Zhu, Mei, additional, Bao, Qiyu, additional, and Zhang, Hailin, additional

Published
2021
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9. Identification of floR Variants Associated With a Novel Tn 4371 -Like Integrative and Conjugative Element in Clinical Pseudomonas aeruginosa Isolates.

Author

Qian C, Liu H, Cao J, Ji Y, Lu W, Lu J, Li A, Zhu X, Shen K, Xu H, Chen Q, Zhou W, Lu H, Lin H, Zhang X, Li Q, Lin X, Li K, Xu T, Zhu M, Bao Q, and Zhang H

Subjects
Animals, Chloramphenicol, Humans, Microbial Sensitivity Tests, Anti-Bacterial Agents pharmacology, Pseudomonas aeruginosa genetics
Abstract

Florfenicol is widely used to control respiratory diseases and intestinal infections in food animals. However, there are increasing reports about florfenicol resistance of various clinical pathogens. floR is a key resistance gene that mediates resistance to florfenicol and could spread among different bacteria. Here, we investigated the prevalence of floR in 430 Pseudomonas aeruginosa isolates from human clinical samples and identified three types of floR genes (designated floR , floR-T1 and floR-T2 ) in these isolates, with floR-T1 the most prevalent (5.3%, 23/430). FloR-T2 was a novel floR variant identified in this study, and exhibited less identity with other FloR proteins than FloRv. Moreover, floR-T1 and floR-T2 identified in P. aeruginosa strain TL1285 were functionally active and located on multi-drug resistance region of a novel incomplete Tn 4371 -like integrative and conjugative elements (ICE) in the chromosome. The expression of the two floR variants could be induced by florfenicol or chloramphenicol. These results indicated that the two floR variants played an essential role in the host's resistance to amphenicol and the spreading of these floR variants might be related with the Tn 4371 family ICE., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflict of interest., (Copyright © 2021 Qian, Liu, Cao, Ji, Lu, Lu, Li, Zhu, Shen, Xu, Chen, Zhou, Lu, Lin, Zhang, Li, Lin, Li, Xu, Zhu, Bao and Zhang.)

Published
2021
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