1. Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study
- Author
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Carlos Gómez-Martínez, Nancy Babio, Jordi Júlvez, Nerea Becerra-Tomás, Miguel Á. Martínez-González, Dolores Corella, Olga Castañer, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, José A. Martínez, Luís Serra-Majem, Ramón Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, José López-Miranda, Aurora Bueno-Cavanillas, José J. Gaforio, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín-Sánchez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Søren Dalsgaard, Carmen Sayón-Orea, José V. Sorlí, Rafael de la Torre, Itziar Abete, Lucas Tojal-Sierra, Francisco J. Barón-López, Noelia Fernández-Brufal, Jadwiga Konieczna, Antonio García-Ríos, Emilio Sacanella, M. Rosa Bernal-López, José M. Santos-Lozano, Cristina Razquin, Andrea Alvarez-Sala, Albert Goday, M. Angeles Zulet, Jessica Vaquero-Luna, Javier Diez-Espino, Aida Cuenca-Royo, Fernando Fernández-Aranda, Mònica Bulló, and Jordi Salas-Salvadó
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Male ,medicine.medical_specialty ,Cognition disorders ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Glycemic Control ,prediabetes ,Type 2 diabetes ,diabetes duration ,Trastorns de la cognició ,Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,chemistry.chemical_compound ,Cognition ,Endocrinology ,0302 clinical medicine ,Insulin resistance ,insulin resistance ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Hypoglycemic Agents ,Cognitive Dysfunction ,Prospective Studies ,Prediabetes ,glycated (glycosylated) hemoglobin ,Cognitive decline ,cognitive function ,Aged ,Glucose Metabolism Disorders ,Original Research ,Glycemic ,Diabetis ,business.industry ,Malalties cardiovasculars ,Diabetes ,Middle Aged ,RC648-665 ,medicine.disease ,3. Good health ,Cardiovascular diseases ,chemistry ,Female ,type 2 diabetes ,Glycated hemoglobin ,Metabolic syndrome ,business ,030217 neurology & neurosurgery - Abstract
The authors wish to thank the PREDIMED-Plus participants and staff for their engagement, as well as to the primary care centers involved in the study. We also thank the Cerca Programme of the Generalitat de Catalunya, and the CIBEROBN, CIBERESP and CIBERDEM initiatives of Instituto de Salud Carlos III in Spain, and the collaborators in the PRIME consortium for helpful input. The first version of the present article has been published in the public repository Research Square as a preprint publication of our work (44). We particularly thank Stephanie Nishi for her assistance with manuscript language revision., Introduction: Type 2 diabetes has been linked to greater cognitive decline, but other glycemic parameters such as prediabetes, diabetes control and treatment, and HOMA-IR and HbA1c diabetes-related biomarkers have shown inconsistent results. Furthermore, there is limited research assessing these relationships in short-term studies. Thus, we aimed to examine 2-year associations between baseline diabetes/glycemic status and changes in cognitive function in older participants at high risk of cardiovascular disease. Methods: We conducted a 2-year prospective cohort study (n=6,874) within the framework of the PREDIMED-Plus study. The participants (with overweight/obesity and metabolic syndrome; mean age 64.9 years; 48.5% women) completed a battery of 8 cognitive tests, and a global cognitive function Z-score (GCF) was estimated. At baseline, participants were categorized by diabetes status (no-diabetes, prediabetes, and, CIBERESP, Generalitat de Catalunya, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Published
- 2021
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