1. The Artificial-Liver Blood-Purification System Can Effectively Improve Hypercytokinemia for COVID-19
- Author
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Liang Yu, Jun Chen, Jing Guo, Jifang Sheng, Huafen Zhang, Yanfei Chen, Yan Zhang, He Xia, Yunqing Qiu, Xiaowei Xu, Kaijin Xu, Lanjuan Li, Ding Shi, and Shuting Wang
- Subjects
lcsh:Immunologic diseases. Allergy ,Adult ,Male ,medicine.medical_specialty ,ARDS ,Coronavirus disease 2019 (COVID-19) ,Immunology ,Blood purification ,hypercytokinemia ,Disease ,IP-10 ,03 medical and health sciences ,0302 clinical medicine ,Artificial liver ,Pandemic ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Intensive care medicine ,Original Research ,Aged ,Aged, 80 and over ,Plasma Exchange ,SARS-CoV-2 ,business.industry ,COVID-19 ,Outbreak ,Middle Aged ,medicine.disease ,Hemoperfusion ,Liver ,artificial-liver blood-purification system ,Cytokines ,Female ,lcsh:RC581-607 ,Cytokine Release Syndrome ,Cytokine storm ,business ,030215 immunology - Abstract
Since the December 2019 outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, the infection has spread locally and globally resulting in a pandemic. As the numbers of confirmed diagnoses and deaths continue to rise, COVID-19 has become the focus of international public health. COVID-19 is highly contagious, and there is no effective treatment yet. New treatment strategies are urgently needed to improve the treatment success rate of severe and critically ill patients. Increasing evidence has shown that a cytokine storm plays an important role in the progression of COVID-19. The artificial-liver blood-purification system (ALS) is expected to improve the outcome of the cytokine storm. In the present study, the levels of cytokines were detected in 12 COVID-19 patients pre- and post-ALS with promising results. The present study shows promising evidence that ALS can block the cytokine storm, rapidly remove the inflammatory mediators, and hopefully, suppress the progression of the disease, thereby providing a new strategy for the clinical treatment of COVID-19.
- Published
- 2020
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