1. A novel signature constructed by super-enhancer-related genes for the prediction of prognosis in hepatocellular carcinoma and associated with immune infiltration
- Author
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Xueyan Wei, Zihan Zhou, Meiying Long, Qiuling Lin, Moqin Qiu, Peiqin Chen, Qiongguang Huang, Jialin Qiu, Yanji Jiang, Qiuping Wen, Yingchun Liu, Runwei Li, Cunli Nong, Qian Guo, Hongping Yu, and Xianguo Zhou
- Subjects
Cancer Research ,Oncology - Abstract
BackgroundSuper-enhancer (SE) refers to a regulatory element with super transcriptional activity, which can enrich transcription factors and drive gene expression. SE-related genes play an important role in the pathogenesis of malignant tumors, including hepatocellular carcinoma (HCC).MethodsThe SE-related genes were obtained from the human super-enhancer database (SEdb). Data from the transcriptome analysis and related clinical information with HCC were obtained from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) database. The upregulated SE-related genes from TCGA-LIHC were identified by the DESeq2R package. Multivariate Cox regression analysis was used to construct a four-gene prognostic signature. According to the median risk score, HCC patients were divided into high-risk and low-risk group patients.ResultsThe Kaplan-Meier (KM) curve showed that a significantly worse prognosis was found for the high-risk group (PConclusionThese results provide further evidence that the unique SE-related gene model could accurately predict the prognosis of HCC.
- Published
- 2023
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