1. The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management
- Author
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Khalid O. Alfarouk, Adil H. H. Bashir, Ahmed N. Aljarbou, AbdelRahman M. Ramadan, Abdel Khalig Muddathir, Sari T. S. AlHoufie, Abdelhamid Hifny, Gamal O. Elhassan, Muntaser E. Ibrahim, Saad S. Alqahtani, Shakir D. AlSharari, Claudiu T. Supuran, Cyril Rauch, Rosa Angela Cardone, Stephan J. Reshkin, Stefano Fais, and Salvador Harguindey
- Subjects
0301 basic medicine ,Cancer Research ,Anaerobic bacterium ,Review ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Normal flora ,Carcinogen ,Related factors ,Helicobacter pylori ,biology ,pH ,business.industry ,gastric cancer ,Cancer ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,Oncology ,inflammation ,030220 oncology & carcinogenesis ,Cancer research ,pharmacology ,business - Abstract
Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current pharmacological approach to treat and prevent its carcinogenicity.
- Published
- 2019
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