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5 results on '"Teixeira, Samuel Cota"'

1. Trypanosoma cruzi P21 recombinant protein modulates Toxoplasma gondii infection in different experimental models of the human maternal–fetal interface

Author

de Souza, Guilherme, primary, Teixeira, Samuel Cota, additional, Fajardo Martínez, Aryani Felixa, additional, Silva, Rafaela José, additional, Luz, Luana Carvalho, additional, Lima Júnior, Joed Pires de, additional, Rosini, Alessandra Monteiro, additional, dos Santos, Natália Carine Lima, additional, de Oliveira, Rafael Martins, additional, Paschoalino, Marina, additional, Barbosa, Matheus Carvalho, additional, Alves, Rosiane Nascimento, additional, Gomes, Angelica Oliveira, additional, da Silva, Claudio Vieira, additional, Ferro, Eloisa Amália Vieira, additional, and Barbosa, Bellisa Freitas, additional

Published
2023
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2. Leaf hydroalcoholic extract and oleoresin from Copaifera multijuga control Toxoplasma gondii infection in human trophoblast cells and placental explants from third-trimester pregnancy

Author

Martínez, Aryani Felixa Fajardo, primary, Teixeira, Samuel Cota, additional, de Souza, Guilherme, additional, Rosini, Alessandra Monteiro, additional, Júnior, Joed Pires de Lima, additional, Melo, Gabriel Nogueira, additional, Blandón, Kelvin Orlando Espinoza, additional, Gomes, Angelica Oliveira, additional, Ambrósio, Sergio Ricardo, additional, Veneziani, Rodrigo Cassio Sola, additional, Bastos, Jairo Kenupp, additional, Martins, Carlos Henrique Gomes, additional, Ferro, Eloisa Amália Vieira, additional, and Barbosa, Bellisa Freitas, additional

Published
2023
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3. The Recombinant Protein Based on Trypanosoma cruzi P21 Interacts With CXCR4 Receptor and Abrogates the Invasive Phenotype of Human Breast Cancer Cells

Author

Borges, Bruna Cristina, primary, Uehara, Isadora Akemi, additional, dos Santos, Marlus Alves, additional, Martins, Flávia Alves, additional, de Souza, Fernanda Carvalho, additional, Junior, Álvaro Ferreira, additional, da Luz, Felipe Andrés Cordero, additional, da Costa, Mylla Spirandelli, additional, Notário, Ana Flávia Oliveira, additional, Lopes, Daiana Silva, additional, Teixeira, Samuel Cota, additional, Teixeira, Thaise Lara, additional, de Castilhos, Patrícia, additional, da Silva, Claudio Vieira, additional, and Silva, Marcelo José Barbosa, additional

Published
2020
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4. The Recombinant Form of Trypanosoma cruzi P21 Controls Infection by Modulating Host Immune Response

Author

Martins, Flávia Alves, primary, dos Santos, Marlus Alves, additional, Santos, Júlia de Gouveia, additional, da Silva, Aline Alves, additional, Borges, Bruna Cristina, additional, da Costa, Mylla Spirandelli, additional, Tavares, Paula Cristina Brígido, additional, Teixeira, Samuel Cota, additional, Brígido, Rebecca Tavares e Silva, additional, Teixeira, Thaise Lara, additional, Rodrigues, Cassiano Costa, additional, Silva, Nadjania Saraiva de Lira, additional, de Oliveira, Rayane Cristina, additional, de Faria, Laura Caroline, additional, Lemes, Marcela Rezende, additional, Zanon, Renata Graciele, additional, Tomiosso, Tatiana Carla, additional, Machado, Juliana Reis, additional, da Silva, Marcos Vinicius, additional, Oliveira, Carlo José Freire, additional, and da Silva, Claudio Vieira, additional

Published
2020
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5. The Trypanosoma cruzi pleiotropic protein P21 orchestrates the intracellular retention and in-vivo parasitism control of virulent Y strain parasites.

Author

Silveira ACA, Uombe NPI, Velikkakam T, Borges BC, Teixeira TL, de Almeida VF, Torres JDA, Pereira CL, de Souza G, Teixeira SC, Servato JPS, Silva MJB, Mineo TWP, Ribas RM, Mortara RA, da Silveira JF, and da Silva CV

Subjects
Animals, Humans, Mice, Cell Line, Cyclin-Dependent Kinase Inhibitor p21 metabolism, Cyclin-Dependent Kinase Inhibitor p21 genetics, Disease Models, Animal, Gene Knockout Techniques, Host-Parasite Interactions, Mice, Inbred BALB C, Parasitemia, Virulence, Chagas Disease parasitology, Protozoan Proteins genetics, Protozoan Proteins metabolism, Trypanosoma cruzi genetics, Trypanosoma cruzi pathogenicity, Trypanosoma cruzi physiology, Trypanosoma cruzi metabolism
Abstract

P21 is a protein secreted by all forms of Trypanosoma cruzi ( T. cruzi ) with recognized biological activities determined in studies using the recombinant form of the protein. In our recent study, we found that the ablation of P21 gene decreased Y strain axenic epimastigotes multiplication and increased intracellular replication of amastigotes in HeLa cells infected with metacyclic trypomastigotes. In the present study, we investigated the effect of P21 in vitro using C2C12 cell lines infected with tissue culture-derived trypomastigotes (TCT) of wild-type and P21 knockout (TcP21 -/- ) Y strain, and in vivo using an experimental model of T. cruzi infection in BALB/c mice. Our in-vitro results showed a significant decrease in the host cell invasion rate by TcP21 -/- parasites as measured by Giemsa staining and cell count in bright light microscope. Quantitative polymerase chain reaction (qPCR) analysis showed that TcP21 -/- parasites multiplied intracellularly to a higher extent than the scrambled parasites at 72h post-infection. In addition, we observed a higher egress of TcP21 -/- trypomastigotes from C2C12 cells at 144h and 168h post-infection. Mice infected with Y strain TcP21 -/- trypomastigotes displayed higher systemic parasitemia, heart tissue parasite burden, and several histopathological alterations in heart tissues compared to control animals infected with scrambled parasites. Therewith, we propose that P21 is important in the host-pathogen interaction during invasion, cell multiplication, and egress, and may be part of the mechanism that controls parasitism and promotes chronic infection without patent systemic parasitemia., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Silveira, Uombe, Velikkakam, Borges, Teixeira, de Almeida, Torres, Pereira, de Souza, Teixeira, Servato, Silva, Mineo, Ribas, Mortara, da Silveira and da Silva.)

Published
2024
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