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Your search keyword '"Xie, Xiaofang"' showing total 23 results
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23 results on '"Xie, Xiaofang"'

5. Corrigendum: Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in zebrafish and SH-SY5Y cells

Author

Zhou, Jie, primary, Peng, Cheng, additional, Li, Qiuju, additional, Yan, Xiaoyu, additional, Yang, Liang, additional, Li, Mengting, additional, Cao, Xiaoyu, additional, Xie, Xiaofang, additional, Chen, Dayi, additional, Rao, Chaolong, additional, Huang, Sizhou, additional, Peng, Fu, additional, and Pan, Xiaoqi, additional

Published
2023
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7. Genome-wide identification and expression analysis of the GRAS transcription in eggplant (Solanum melongena L.)

Author

Yang, Ting, Li, Cheng, Zhang, Hui, Wang, Jingyu, Xie, Xiaofang, and Wen, Yongxian

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

GRAS proteins are plant-specific transcription factors and play important roles in plant growth, development, and stress responses. In this study, a total of 48 GRAS genes in the eggplant (S. melongena) genome were identified. These genes were distributed on 11 chromosomes unevenly, with amino acid lengths ranging from 417 to 841 aa. A total of 48 GRAS proteins were divided into 13 subgroups based on the maximum likelihood (ML) model. The gene structure showed that 60.42% (29/48) of SmGRASs did not contain any introns. Nine pairs of SmGRAS appeared to have a collinear relationship, and all of them belonged to segmental duplication. Four types of cis-acting elements, namely, light response, growth and development, hormone response, and stress response, were identified by a cis-acting element predictive analysis. The expression pattern analysis based on the RNA-seq data of eggplant indicated that SmGRASs were expressed differently in various tissues and responded specifically to cold stress. In addition, five out of ten selected SmGRASs (SmGRAS2/28/32/41/44) were upregulated under cold stress. These results provided a theoretical basis for further functional study of GRAS genes in eggplant.

Published
2022

12. Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

Author

Zhou, Jie, primary, Peng, Cheng, additional, Li, Qiuju, additional, Yan, Xiaoyu, additional, Yang, Liang, additional, Li, Mengting, additional, Cao, Xiaoyu, additional, Xie, Xiaofang, additional, Chen, Dayi, additional, Rao, Chaolong, additional, Huang, Sizhou, additional, Peng, Fu, additional, and Pan, Xiaoqi, additional

Published
2022
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15. Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review

Author

Chen Junren, Xie Xiaofang, Zhang Huiqiong, Li Gangmin, Yin Yanpeng, Cao Xiaoyu, Gao Yuqing, Li Yanan, Zhang Yue, Peng Fu, and Peng Cheng

Subjects
Drug, media_common.quotation_subject, Hirudin, RM1-950, Review, Traditional Chinese medicine, Pharmacology, wound repair, Thrombin, Pharmacokinetics, Antithrombotic, natural hirudin, Medicine, Pharmacology (medical), recombinant hirudin, anti-fibrosis, media_common, anti-thrombosis, mechanisms, biology, business.industry, biology.organism_classification, Hirudo medicinalis, Toxicity, Therapeutics. Pharmacology, business, medicine.drug
Abstract

Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far. Hirudin has been demonstrated to possess potent anti-thrombotic effect in previous studies. Recently, increasing researches have focused on the anti-thrombotic activity of the derivatives of hirudin, mainly because these derivatives have stronger antithrombotic activity and lower bleeding risk. Additionally, various bioactivities of hirudin have been reported as well, including wound repair effect, anti-fibrosis effect, effect on diabetic complications, anti-tumor effect, anti-hyperuricemia effect, effect on cerebral hemorrhage, and others. Therefore, by collecting and summarizing publications from the recent two decades, the pharmacological activities, pharmacokinetics, novel preparations and derivatives, as well as toxicity of hirudin were systematically reviewed in this paper. In addition, the clinical application, the underlying mechanisms of pharmacological effects, the dose-effect relationship, and the development potential in new drug research of hirudin were discussed on the purpose of providing new ideas for application of hirudin in treating related diseases.

Published
2021

20. Genetic Diversity of Carbapenem-Resistant Enterobacteriaceae (CRE) Clinical Isolates From a Tertiary Hospital in Eastern China

Author

Miao, Minhui, primary, Wen, Huiyan, additional, Xu, Ping, additional, Niu, Siqiang, additional, Lv, Jingnan, additional, Xie, Xiaofang, additional, Mediavilla, José R., additional, Tang, Yi-Wei, additional, Kreiswirth, Barry N., additional, Zhang, Xia, additional, Zhang, Haifang, additional, Du, Hong, additional, and Chen, Liang, additional

Published
2019
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