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Your search keyword '"Zhang, Fangyuan"' showing total 16 results
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16 results on '"Zhang, Fangyuan"'

9. The Superoxide Dismutase Gene Family in Nicotiana tabacum: Genome-Wide Identification, Characterization, Expression Profiling and Functional Analysis in Response to Heavy Metal Stress

Author

Huo, Chunsong, He, Linshen, Yu, Ting, Ji, Xue, Li, Rui, Zhu, Shunqin, Zhang, Fangyuan, Xie, He, and Liu, Wanhong

Subjects
Plant Science
Abstract

Superoxide dismutases (SODs) play an important role in protecting plants against ROS toxicity induced by biotic and abiotic stress. Recent studies have shown that the SOD gene family is involved in plant growth and development; however, knowledge of the SOD gene family in tobacco is still limited. In the present study, the SOD gene family was systematically characterized in the tobacco genome. Based on the conserved motif and phylogenetic tree, 15 NtSOD genes were identified and classified into three subgroups, including 5 NtCSDs, 7 NtFSDs and 3 NtMSDs. The predicted results of the transport peptide or signal peptide were consistent with their subcellular localization. Most NtSOD genes showed relatively well-maintained exon-intron and motif structures in the same subgroup. An analysis of cis-acting elements in SOD gene promoters showed that NtSOD expression was regulated by plant hormones, defense and stress responses, and light. In addition, multiple transcription factors and miRNAs are predicted to be involved in the regulation of NtSOD gene expression. The qPCR results indicated specific spatial and temporal expression patterns of the NtSOD gene family in different tissues and developmental stages, and this gene family played an important role in protecting against heavy metal stress. The results of functional complementation tests in the yeast mutant suggested that NtCSD1a, NtFSD1e and NtMSD1b scavenge ROS produced by heavy metal stress. This study represents the first genome-wide analysis of the NtSOD gene family, which lays a foundation for a better understanding of the function of the NtSOD gene family and improving the tolerance of plants to heavy metal toxicity.

Published
2022

11. A PD-L1 Negative Advanced Gastric Cancer Patient With a Long Response to PD-1 Blockade After Failure of Systematic Treatment: A Case Report

Author

Zhang, Fangyuan, Zhang, Jieying, Zhao, Lei, Zhai, Menglan, Zhang, Tao, and Yu, Dandan

Subjects
PD-L1, MSS, lymph node metastasis, Immunology, Immunology and Allergy, Case Report, immunotherapy, Immunologic diseases. Allergy, RC581-607, advanced gastric cancer, pMMR
Abstract

BackgroundIt was widely accepted that programmed death-ligand 1 (PD-L1) positive, tumor mutational burden-high (TMB-H) or microsatellite instability-high (MSI-H) tumor are prone to have better treatment response to immune checkpoint blockade. The value of immune checkpoint blockade in PD-L1 negative gastric cancer patients has been questioned due to lower objective response rate (ORR).Case PresentationWe report an unusual case of a PD-L1 negative, proficient mismatch repair (pMMR)/microsatellite stability (MSS), tumor mutational burden-low (TMB-L) gastric cancer patient who achieved good response to immune checkpoint blockade after failure of systematic treatment. Multiple lymph nodes and bone metastases are the main characteristics of this patient. The patient survived for more than 30 months after diagnosis.ConclusionsThis case suggested that PD-L1 negative gastric cancer patient may also benefit from immune checkpoint blockade. In gastric cancer, patients with lymph node metastasis may be potential beneficiaries.

Published
2021

14. High-Level Patchoulol Biosynthesis in Artemisia annua L.

Author

Fu, Xueqing, primary, Zhang, Fangyuan, additional, Ma, Yanan, additional, Hassani, Danial, additional, Peng, Bowen, additional, Pan, Qifang, additional, Zhang, Yuhua, additional, Deng, Zhongxiang, additional, Liu, Wenbo, additional, Zhang, Jixiu, additional, Han, Lei, additional, Chen, Dongfang, additional, Zhao, Jingya, additional, Li, Ling, additional, Sun, Xiaofen, additional, and Tang, Kexuan, additional

Published
2021
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