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Your search keyword '"Zhao, Yuwen"' showing total 17 results
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17 results on '"Zhao, Yuwen"'

1. Evaluation of the role of FMR1 CGG repeat allele in Parkinson’s disease from the Chinese population

Author

Chen, Juan, primary, Zhao, Yuwen, additional, Zhou, Xun, additional, Xue, Jin, additional, Xiao, Qiao, additional, Pan, Hongxu, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Li, Jian, additional, Zhu, Liping, additional, Zhou, Zhou, additional, Yang, Yang, additional, Xu, Qian, additional, Sun, Qiying, additional, Yan, Xinxiang, additional, Tan, Jieqiong, additional, Li, Jinchen, additional, Guo, Jifeng, additional, Duan, Ranhui, additional, Tang, Beisha, additional, Yu, Qiao, additional, and Liu, Zhenhua, additional

Published
2023
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2. Genetic analysis of dystonia-related genes in Parkinson's disease

Author

Wang, Yige, primary, Zhao, Yuwen, additional, Pan, Hongxu, additional, Zeng, Qian, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Zhou, Zhou, additional, Xu, Qian, additional, Sun, Qiying, additional, Tan, Jieqiong, additional, Yan, Xinxiang, additional, Li, Jinchen, additional, Guo, Jifeng, additional, Tang, Beisha, additional, Yu, Qiao, additional, and Liu, Zhenhua, additional

Published
2023
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6. Subtyping of early-onset Parkinson’s disease using cluster analysis: A large cohort study

Author

Zhou, Zhou, primary, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Zhao, Yuwen, additional, Pan, Hongxu, additional, Wu, Juan, additional, Xu, Qian, additional, Chen, Yase, additional, Sun, Qiying, additional, Wu, Xinyin, additional, Zhu, Jianping, additional, Wu, Xuehong, additional, Li, Jianhua, additional, Yan, Xinxiang, additional, Guo, Jifeng, additional, Tang, Beisha, additional, Lei, Lifang, additional, and Liu, Zhenhua, additional

Published
2022
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8. Genetic Analysis of Six Transmembrane Protein Family Genes in Parkinson’s Disease in a Large Chinese Cohort

Author

Zhao, Yuwen, primary, Zhang, Kailin, additional, Pan, Hongxu, additional, Wang, Yige, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Xu, Qian, additional, Sun, Qiying, additional, Tan, Jieqiong, additional, Yan, Xinxiang, additional, Li, Jinchen, additional, Guo, Jifeng, additional, Tang, Beisha, additional, and Liu, Zhenhua, additional

Published
2022
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9. Profiling the Genome-Wide Landscape of Short Tandem Repeats by Long-Read Sequencing

Author

Liu, Zhenhua, Zhao, Guihu, Xiao, Yuhui, Zeng, Sheng, Yuan, Yanchun, Zhou, Xun, Fang, Zhenghuan, He, Runcheng, Li, Bin, Zhao, Yuwen, Pan, Hongxu, Wang, Yige, Yu, Guoliang, Peng, I-Feng, Wang, Depeng, Meng, Qingtuan, Xu, Qian, Sun, Qiying, Yan, Xinxiang, Shen, Lu, Jiang, Hong, Xia, Kun, Wang, Junling, Guo, Jifeng, Liang, Fan, Li, Jinchen, and Tang, Beisha

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

Background: Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases and the regulation of gene expression. Long-read sequencing (LRS) offers a potential solution to genome-wide STR analysis. However, characterizing STRs in human genomes using LRS on a large population scale has not been reported.Methods: We conducted the large LRS-based STR analysis in 193 unrelated samples of the Chinese population and performed genome-wide profiling of STR variation in the human genome. The repeat dynamic index (RDI) was introduced to evaluate the variability of STR. We sourced the expression data from the Genotype-Tissue Expression to explore the tissue specificity of highly variable STRs related genes across tissues. Enrichment analyses were also conducted to identify potential functional roles of the high variable STRs.Results: This study reports the large-scale analysis of human STR variation by LRS and offers a reference STR database based on the LRS dataset. We found that the disease-associated STRs (dSTRs) and STRs associated with the expression of nearby genes (eSTRs) were highly variable in the general population. Moreover, tissue-specific expression analysis showed that those highly variable STRs related genes presented the highest expression level in brain tissues, and enrichment pathways analysis found those STRs are involved in synaptic function-related pathways.Conclusion: Our study profiled the genome-wide landscape of STR using LRS and highlighted the highly variable STRs in the human genome, which provide a valuable resource for studying the role of STRs in human disease and complex traits.

Published
2022

12. Characteristics of Autonomic Dysfunction in Parkinson’s Disease: A Large Chinese Multicenter Cohort Study

Author

Zhou, Zhou, primary, Zhou, Xiaoting, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Zhu, Liping, additional, Qin, Lixia, additional, Wang, Yige, additional, Pan, Hongxu, additional, Zhao, Yuwen, additional, Sun, Qiying, additional, Xu, Qian, additional, Wu, Xinyin, additional, Yan, Xinxiang, additional, Guo, Jifeng, additional, Tang, Beisha, additional, and Liu, Zhenhua, additional

Published
2021
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13. Gene4PD: A Comprehensive Genetic Database of Parkinson’s Disease

Author

Li, Bin, primary, Zhao, Guihu, additional, Zhou, Qiao, additional, Xie, Yali, additional, Wang, Zheng, additional, Fang, Zhenghuan, additional, Lu, Bin, additional, Qin, Lixia, additional, Zhao, Yuwen, additional, Zhang, Rui, additional, Jiang, Li, additional, Pan, Hongxu, additional, He, Yan, additional, Wang, Xiaomeng, additional, Luo, Tengfei, additional, Zhang, Yi, additional, Wang, Yijing, additional, Chen, Qian, additional, Liu, Zhenhua, additional, Guo, Jifeng, additional, Tang, Beisha, additional, and Li, Jinchen, additional

Published
2021
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14. Olfactory Dysfunction Predicts Disease Progression in Parkinson’s Disease: A Longitudinal Study

Author

He, Runcheng, primary, Zhao, Yuwen, additional, He, Yan, additional, Zhou, Yangjie, additional, Yang, Jinxia, additional, Zhou, Xiaoting, additional, Zhu, Liping, additional, Zhou, Xun, additional, Liu, Zhenhua, additional, Xu, Qian, additional, Sun, Qiying, additional, Tan, Jieqiong, additional, Yan, Xinxiang, additional, Tang, Beisha, additional, and Guo, Jifeng, additional

Published
2020
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16. The Discriminative Power of Different Olfactory Domains in Parkinson's Disease

Author

Zhao, Yuwen, primary, He, Yan, additional, He, Runcheng, additional, Zhou, Yangjie, additional, Pan, Hongxu, additional, Zhou, Xiaoting, additional, Zhu, Liping, additional, Zhou, Xun, additional, Liu, Zhenhua, additional, Xu, Qian, additional, Sun, Qiying, additional, Tan, Jieqiong, additional, Yan, Xinxiang, additional, Tang, Beisha, additional, and Guo, Jifeng, additional

Published
2020
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