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1. Brief Note Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China.

Author

Chen LP, E GX, Zhao YJ, Na RS, Zhao ZQ, Zhang JH, Ma YH, Sun YW, Zhong T, Zhang HP, and Huang YF

Subjects
Animals, Animals, Domestic, China, Exons, Goats classification, Goats immunology, HLA-DR alpha-Chains immunology, Introns, Open Reading Frames, Untranslated Regions, Goats genetics, HLA-DR alpha-Chains genetics, Polymorphism, Genetic
Abstract

DRA encodes the alpha chain of the DR heterodimer, is closely linked to DRB and is considered almost monomorphic in major histocompatibility complex region. In this study, we identified the exon 2 of DRA to evaluate the immunogenetic diversity of Chinese south indigenous goat. Two single nucleotide polymorphisms in an untranslated region and one synonymous substitution in coding region were identified. These data suggest that high immunodiversity in native Chinese population.

Published
2015
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