1. Bevacizumab in the treatment of metastatic colorectal cancer.
- Author
-
Caprioni F and Fornarini G
- Subjects
- Angiogenesis Inhibitors adverse effects, Angiogenesis Inhibitors pharmacokinetics, Angiogenesis Inhibitors therapeutic use, Antibodies, Monoclonal adverse effects, Antibodies, Monoclonal pharmacokinetics, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Bevacizumab, Clinical Trials, Phase II as Topic statistics & numerical data, Clinical Trials, Phase III as Topic statistics & numerical data, Drug-Related Side Effects and Adverse Reactions, Humans, Treatment Outcome, Vascular Endothelial Growth Factor A drug effects, Antibodies, Monoclonal therapeutic use, Colorectal Neoplasms drug therapy, Neoplasm Metastasis drug therapy
- Abstract
Angiogenesis is essential for tumor growth and metastasis, and has become a useful target for novel biological agents. Vascular endothelial growth factor (VEGF) is one of the most important angiogenesis regulators. Bevacizumab is a recombinant humanized anti-VEGF monoclonal antibody recently approved in Europe and the USA for first- and second-line therapy (in combination with chemotherapy) for metastatic colorectal cancer. It has a proven impact on survival, as demonstrated in large Phase III clinical trials. Treatment with bevacizumab is generally well tolerated, with hypertension and arterial thromboembolic events being the main side effects. Currently, its role in the adjuvant setting, in combination with chemotherapy, is being evaluated in large Phase III clinical trials.
- Published
- 2007
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