1. Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.
- Author
-
Strong AL, Jones RB Jr, Glowacki J, Boue SM, Burow ME, and Bunnell BA
- Subjects
- Adult, Bone Marrow Cells cytology, Bone Marrow Cells drug effects, Cell Separation, Estradiol analogs & derivatives, Estradiol pharmacology, Estrogen Receptor alpha metabolism, Female, Fulvestrant, Humans, Mesenchymal Stem Cells drug effects, Middle Aged, Tissue Donors, Young Adult, Cell Differentiation drug effects, Cellular Senescence drug effects, Flavonols pharmacology, Mesenchymal Stem Cells cytology, Osteogenesis drug effects
- Abstract
Aim: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential., Methods: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old)., Results: BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling., Conclusion: The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.
- Published
- 2017
- Full Text
- View/download PDF