1. Localization and mobility of glucose-coated gold nanoparticles within the brain
- Author
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Ignacio A. Romero, David Male, Canan Yilmaz, Heather A. Davies, Mehmet Kaya, Phil Williams, Nurcan Orhan, Basil Sharrack, and Radka Gromnicova
- Subjects
Male ,Biomedical Engineering ,Metal Nanoparticles ,Medicine (miscellaneous) ,Nanoparticle ,Bioengineering ,Nanotechnology ,02 engineering and technology ,Development ,Blood–brain barrier ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,medicine ,Animals ,Distribution (pharmacology) ,Tissue Distribution ,General Materials Science ,Particle Size ,Rats, Wistar ,Microvessel ,Brain ,021001 nanoscience & nanotechnology ,Cytosol ,Glucose ,medicine.anatomical_structure ,Blood-Brain Barrier ,Colloidal gold ,Drug delivery ,Biophysics ,Gold ,Electron microscope ,0210 nano-technology ,030217 neurology & neurosurgery - Abstract
Aim: To identify the localization of glucose-coated gold nanoparticles within cells of the brain after intravascular infusion which may point to the mechanism by which they cross the blood–brain barrier. Materials & methods: Tissue distribution of the nanoparticles was measured by inductively-coupled-mass spectrometry and localization within the brain by histochemistry and electron microscopy. Results & conclusion: Nanoparticles were identified within neurons and glial cells more than 10 μm from the nearest microvessel within 10 min of intracarotid infusion. Their distribution indicated movement across the endothelial cytosol, and direct transfer between cells of the brain. The rapid movement of this class of nanoparticle (
- Published
- 2016
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