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Your search keyword '"Tiwari, Arun"' showing total 11 results
Start Over Author "Tiwari, Arun" Publisher future medicine ltd
11 results on '"Tiwari, Arun"'

1. Liver enzyme CYP2D6 gene and tardive dyskinesia

Author

Lu, Justin Y, primary, Tiwari, Arun K, additional, Freeman, Natalie, additional, Zai, Gwyneth C, additional, Luca, Vincenzo de, additional, Müller, Daniel J, additional, Tampakeras, Maria, additional, Herbert, Deanna, additional, Emmerson, Heather, additional, Cheema, Sheraz Y, additional, King, Nicole, additional, Voineskos, Aristotle N, additional, Potkin, Steven G, additional, Lieberman, Jeffrey A, additional, Meltzer, Herbert Y, additional, Remington, Gary, additional, Kennedy, James L, additional, and Zai, Clement C, additional

Published
2020
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4. Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes

Author

Pouget, Jennie G, primary, Gonçalves, Vanessa F, additional, Nurmi, Erika L, additional, P Laughlin, Christopher, additional, Mallya, Karyn S, additional, McCracken, James T, additional, Aman, Michael G, additional, McDougle, Christopher J, additional, Scahill, Lawrence, additional, Misener, Virginia L, additional, Tiwari, Arun K, additional, Zai, Clement C, additional, Brandl, Eva J, additional, Felsky, Daniel, additional, Leung, Amy Q, additional, Lieberman, Jeffrey A, additional, Meltzer, Herbert Y, additional, Potkin, Steven G, additional, Niedling, Charlotte, additional, Steimer, Werner, additional, Leucht, Stefan, additional, Knight, Jo, additional, Müller, Daniel J, additional, and Kennedy, James L, additional

Published
2015
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11. Association of the alpha 2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans.

Author

Sickert L, Müller DJ, Tiwari AK, Shaikh S, Zai C, De Souza R, De Luca V, Meltzer HY, Lieberman JA, and Kennedy JL

Subjects
Adult, Black or African American genetics, Double-Blind Method, Female, Genome-Wide Association Study methods, Humans, Male, Middle Aged, Prospective Studies, Antipsychotic Agents adverse effects, Polymorphism, Genetic genetics, Receptors, Adrenergic, alpha-2 genetics, Weight Gain drug effects, Weight Gain genetics, White People genetics
Abstract

Aims: To investigate the -1291 C/G promoter polymorphism (rs1800544) of the adrenergic alpha-2A receptor (ADRA2A) with clozapine-/olanzapine-induced weight gain in European-Americans and African-Americans. The alpha-adrenergic receptors inhibit lipolysis in the adipose tissue and are involved in weight gain regulation. Moreover, two previous studies indicated an association with antipsychotic-induced weight gain with the same polymorphism in Asian populations., Materials & Methods: We analyzed a relatively large (n=129) and well-characterized group of patients and monitored them for a period of 6-14 weeks. Our refined sample consisted of 60 European-Americans and 39 African-Americans on clozapine or olanzapine, prospectively., Results: In European-Americans, we observed a significant difference in weight gain across the genotypic categories (p=0.046). The carriers of the C allele gained more weight compared with the subjects homozygous for the GG allele (CC + CG vs GG; 3.73 +/- 4.13 kg vs 0.23 +/- 2.92 kg; p=0.013). We did not find a significant association in African-Americans, although the sample size was probably too small., Conclusion: Our observations suggest a possible role of ADRA2A polymorphisms in clozapine-/olanzpaine-induced weight gain in subjects of European descent.

Published
2009
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