1. Long noncoding RNA as an indicator differentiating schizophrenia from major depressive disorder and generalized anxiety disorder in nonpsychiatric hospital
- Author
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Liyi Zhang, Aifang Zhong, Wei Niu, Lingming Kong, Mingjun He, Xuelian Cui, Kunhong Jiang, Jim Lu, Shengdong Chen, Wanshuai Li, and Qiao-li Zhang
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,endocrine system ,medicine.medical_specialty ,Generalized anxiety disorder ,Clinical Biochemistry ,Down-Regulation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,Drug Discovery ,medicine ,Humans ,Psychiatry ,Depression (differential diagnoses) ,Depressive Disorder, Major ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Biochemistry (medical) ,Case-control study ,Middle Aged ,medicine.disease ,Anxiety Disorders ,Long non-coding RNA ,Up-Regulation ,030104 developmental biology ,Schizophrenia ,Case-Control Studies ,Biomarker (medicine) ,Major depressive disorder ,Anxiety ,Female ,RNA, Long Noncoding ,medicine.symptom ,business ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Aim: Depression and anxiety are common symptoms for schizophrenia (SZ) in the early onset. This study aimed to determine whether long noncoding RNAs (lncRNAs) can be indicators for diagnosing SZ in nonpsychiatric hospitals. Materials & methods: Three upregulated SZ lncRNAs, six downregulated major depressive disorder (MDD) lncRNAs and three upregulated generalized anxiety disorder (GAD) lncRNAs were cross-validated in 45 SZ patients, 48 MDD patients, 52 GAD patients and 40 controls by reverse transcription-PCR. Results: Three SZ lncRNAs were significantly downregulated in GAD patients. The expression of the six MDD lncRNAs showed an opposite trend in SZ patients, and the three GAD lncRNAs also showed significant differences between SZ and GAD patients. Conclusion: The three upregulated SZ lncRNAs are not entirely replicated in MDD and GAD patients and could be potential indicators for distinguishing SZ from MDD and GAD in nonpsychiatric hospital.
- Published
- 2017
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